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Gliotoxin

Catalog No. TN1694 CAS 67-99-2

Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. Gliotoxin is a mycotoxin produced by several moulds such as Aspergillus fumigatus. Gliotoxin activates PKA and increases intracellular cAMP concentration and inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis.

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Gliotoxin, CAS 67-99-2

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Purity 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

The structures of these compounds (1-12) were determined mainly by the extensive NMR, ESIMS spectra data and by comparison with previously described compounds. Besides, anti-tuberculosis, cytotoxic, antibacterial, COX-2 inhibitory and antiviral activities of these compounds were evaluated[1]

Molecular Weight	326.4
Formula	C13H14N2O4S2
CAS No.	67-99-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Chloroform: 10 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Antituberculosis compounds from a deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01.Nat Prod Res. 2017 Aug;31(16):1958-1962.

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