Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. Gliotoxin is a mycotoxin produced by several moulds such as Aspergillus fumigatus. Gliotoxin activates PKA and increases intracellular cAMP concentration and inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 143.00 | |
5 mg | 35 days | $ 633.00 | |
10 mg | 35 days | $ 1,050.00 |
Description | Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. Gliotoxin is a mycotoxin produced by several moulds such as Aspergillus fumigatus. Gliotoxin activates PKA and increases intracellular cAMP concentration and inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis. |
Targets&IC50 | Mycobacterium tuberculosis:<0.03 μM(MIC50) |
In vitro | The structures of these compounds (1-12) were determined mainly by the extensive NMR, ESIMS spectra data and by comparison with previously described compounds. Besides, anti-tuberculosis, cytotoxic, antibacterial, COX-2 inhibitory and antiviral activities of these compounds were evaluated[1] |
Molecular Weight | 326.39 |
Formula | C13H14N2O4S2 |
CAS No. | 67-99-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Chloroform: 10 mg/mL
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Gliotoxin 67-99-2 Apoptosis Cytoskeletal Signaling Immunology/Inflammation Microbiology/Virology Neuroscience NF-Κb Stem Cells Tyrosine Kinase/Adaptors NF-κB COX Wnt/beta-catenin Antibacterial PKA Antifection Aspergillin Fungal Inhibitor Bacterial inhibit Protein kinase A Nuclear factor-κB Nuclear factor-kappaB Antibiotic inhibitor