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Glaucocalyxin B

Catalog No. TQ0309 CAS 80508-81-2

Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM).

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Glaucocalyxin B, CAS 80508-81-2

Pack Size	Availability	Price/USD	Quantity
1 mg	In stock	$ 166.00
5 mg	In stock	$ 365.00

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Purity: 99.13%

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Description	Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM).
Targets&IC50	HL-60 cell Growth:5.86 μM (IC50)
In vitro	Glaucocalyxin A (GlnA) and (GlnB) dose-dependently decrease the growth of HL-60 cells (IC50s: 6.15 and 5.86 μM at 24 h). Both Gln A and B could induce apoptosis, G2/M-phase cycle arrest, DNA damage and the accumulation of reactive oxygen species (ROS) in HL-60 cells[1]. GlnB inhibits the proliferation of human cervical cancer cells in vitro through the induction of apoptosis and autophagy, which may be mediated by the phosphatidylinositol 4,5 bisphosphate 3 kinase/Akt signaling pathway. Treatment with GlnB inhibits the proliferation of HeLa and SiHa cervical cancer cell lines in a dose-dependent manner. GlnB increases the apoptotic cell population and enhanced poly (ADP ribose) polymerase 1 cleavage [2].
Cell Research	The microglia cell viability is assessed by MTT assay. Cells are seeded in 96-well plates at the density of 5 × 10^4 cells/well. The cell culture supernatant is discarded after treatment with various agents, and then 30 μL of MTT (0.5 mg/mL) solution is added into each well. After incubation for 4 h at 37 °C, 100 μL of DMSO is added into each well to dissolve the formazan dye, and then the absorbance of solubilized formazan is measured by microplate reader [3].
Source	Natural Products > Lamiaceae > Isodon

Molecular Weight	374.47
Formula	C22H30O5
CAS No.	80508-81-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Yang WH, et al. Glaucocalyxin A and B-induced cell death is related to GSH perturbation in human leukemia HL-60 cells. Anticancer Agents Med Chem. 2013 Oct;13(8):1280-90. 2. Pan Y, et al. Glaucocalyxin B induces apoptosis and autophagy in human cervical cancer cells. Mol Med Rep. 2016 Aug;14(2):1751-5. 3. Gan P, et al. Anti-inflammatory effects of glaucocalyxin B in microglia cells. J Pharmacol Sci. 2015 May;128(1):35-46.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library RO5 Drug-like Natural Product Library Rare Natural Compound Library

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Keywords

Glaucocalyxin B 80508-81-2 Autophagy Inhibitor inhibit inhibitor

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