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Garcinone D

Garcinone D
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Purity:99.94%
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Garcinone D

Catalog No. TN1674Cas No. 107390-08-9
Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal aromatase inhibitory activity. Garcinone D inhibits p65 activation with IC50 values of 3.2 microM.
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Pack SizePriceAvailabilityQuantity
1 mg$163In Stock
5 mg$490In Stock
10 mg$715In Stock
25 mg$1,090In Stock
50 mg$1,480In Stock
1 mL x 10 mM (in DMSO)$468In Stock
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Product Introduction

Bioactivity
Description
Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal aromatase inhibitory activity. Garcinone D inhibits p65 activation with IC50 values of 3.2 micr
In vitro
Meanwhile, the root bark of the plant furnished six xanthones, namely alpha-mangostin (2), beta-mangostin (3), gamma-mangostin (4), Garcinone D (5), mangostanol (6), and gartanin (7). The hexane and chloroform extracts of the root bark of G. mangostana as well as the hexane extract of the stem bark were found to be active against the CEM-SS cell line. gamma-Mangostin (4) showed good activity with a very low IC(50) value of 4.7 microg/ml, while alpha-mangostin (2), mangostanol (6), and Garcinone D (5) showed significant activities with IC(50) values of 5.5, 9.6, and 3.2 microg/ml, respectively[1]
Chemical Properties
Molecular Weight428.47
FormulaC24H28O7
Cas No.107390-08-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 50 mg/mL (116.69 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3339 mL11.6694 mL23.3389 mL116.6943 mL
5 mM0.4668 mL2.3339 mL4.6678 mL23.3389 mL
10 mM0.2334 mL1.1669 mL2.3339 mL11.6694 mL
20 mM0.1167 mL0.5835 mL1.1669 mL5.8347 mL
50 mM0.0467 mL0.2334 mL0.4668 mL2.3339 mL
100 mM0.0233 mL0.1167 mL0.2334 mL1.1669 mL

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