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Fludrocortisone

Name: Fludrocortisone
Brand: TargetMol
SKU: T1666L
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Fludrocortisone acetate, Florinef, Astonin, 9α-fluorohydrocortisone, 9α-fluorocortisol, 9α-Fluorcortisol, 9α-Fludrocortisone) Copy Product Info

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Synonyms: Fludrocortisone acetate, Florinef, Astonin, 9α-fluorohydrocortisone, 9α-fluorocortisol, 9α-Fluorcortisol, 9α-Fludrocortisone

Catalog No. T1666L Copy Product Info

Purity: 98.66%

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Fludrocortisone (Florinef) is a synthetic corticosteroid with moderate glucocorticoid potency and greater mineralocorticoid potency. Fludrocortisone is in research use for the treatment of hypotension.[3]

Cas No. 127-31-1

Pack Size	Price	USA Stock	Global Stock
1 mg	$30	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$110	In Stock	In Stock
25 mg	$181	In Stock	In Stock
50 mg	$263	-	In Stock
100 mg	$396	-	In Stock
1 mL x 10 mM (in DMSO)	$64	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:98.66%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Fludrocortisone (Florinef) is a synthetic corticosteroid with moderate glucocorticoid potency and greater mineralocorticoid potency. Fludrocortisone is in research use for the treatment of hypotension.[3]
In vitro	METHODS: MIO-M1 cells were selected to study the anti-inflammatory effects of Fludrocortisone （Florinef） under IL-1β or TNF-α stimulation. Fludrocortisone was added to the culture medium at a concentration of 1 μg/μl, and 1 ng/μl of IL-1β or TNF-α was added at the same time. RESULTS Fludrocortisone reduced the expression of CCL2, IL-6, and IL-8 to baseline levels after TNF-α stimulation. [2]
In vivo	METHODS: Wistar rats were treated intravenously with Fludrocortisone （Florinef） (5 and 20 μg/kg). The effects of a single dose of fludrocortisone on systolic blood pressure in normal and endotoxemic rats were evaluated until 2 h after treatment injection and in vitro vasoconstriction to phenylephrine in mesenteric artery rings 3 h after treatment. RESULTS Fludrocortisone increased systolic blood pressure (P < 0.001), but more in endotoxemic than in normal animals. Fludrocortisone significantly improved the contractile response to phenylephrine (P = 0.039 and P = 0.007, respectively). [1]
Synonyms	Fludrocortisone acetate, Florinef, Astonin, 9α-fluorohydrocortisone, 9α-fluorocortisol, 9α-Fluorcortisol, 9α-Fludrocortisone

Chemical Properties

Molecular Weight	380.45
Formula	C₂₁H₂₉FO₅
Cas No.	127-31-1
Smiles	C[C@]12C[C@H](O)C3(F)[C@@H](CCC4=CC(=O)CC[C@]34C)C1CCC2(O)C(=O)CO
Relative Density.	1.3g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55.5 mg/mL (145.88 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: < 5.56 mg/mL (14.61 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5.56 mg/mL (14.61 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6285 mL	13.1423 mL	26.2847 mL	131.4233 mL
5 mM	0.5257 mL	2.6285 mL	5.2569 mL	26.2847 mL
10 mM	0.2628 mL	1.3142 mL	2.6285 mL	13.1423 mL
20 mM	0.1314 mL	0.6571 mL	1.3142 mL	6.5712 mL
50 mM	0.0526 mL	0.2628 mL	0.5257 mL	2.6285 mL
100 mM	0.0263 mL	0.1314 mL	0.2628 mL	1.3142 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Mineralocorticoid ReceptorFludrocortisone9alpha-fluorohydrocortisone9alpha-fluorocortisol9alpha-Fluorcortisol9alpha-Fludrocortisone9a-fluorohydrocortisone9a-fluorocortisol9a-Fluorcortisol9a-Fludrocortisone

Related Tags: Fludrocortisone chemical structure | Fludrocortisone in vivo | Fludrocortisone in vitro | Fludrocortisone formula | Fludrocortisone molecular weight