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Autophagy Autophagy Flavoglaucin

Flavoglaucin

Catalog No. TN4064   CAS 523-73-9

Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannabinoid receptors. Flavoglaucin appears to be an antitumor promoter, it also has anti-inflammatory effects, it shows inhibitory effects on inflammatory mediators via the induction of heme oxygenase-1 in lipopolysaccharide-stimulated RAW264.7 macrophages. Flavoglaucin exhibits a significant radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with theIC(50) value of 11.3 microM.

Flavoglaucin, CAS 523-73-9
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannabinoid receptors. Flavoglaucin appears to be an antitumor promoter, it also has anti-inflammatory effects, it shows inhibitory effects on inflammatory mediators via the induction of heme oxygenase-1 in lipopolysaccharide-stimulated RAW264.7 macrophages. Flavoglaucin exhibits a significant radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with theIC(50) value of 11.3 microM.
Targets&IC50 COX ,   HO-1 ,   IL Receptor ,   NF-κB ,   NO ,   NOS ,   Nrf2 ,   PGE ,   PTP1B ,   TNF-α
Molecular Weight 304.43
Formula C19H28O3
CAS No. 523-73-9

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Benzyl derivatives with in vitro binding affinity for human opioid and cannabinoid receptors from the fungus Eurotium repens. J Nat Prod. 2011 Jul 22;74(7):1636-9. 2. Evaluation of flavoglaucin, its derivatives and pyranonigrins produced by molds used in fermented foods for inhibiting tumor promotion. Biosci Biotechnol Biochem. 2010;74(5):1120-2. 3. A new radical scavenging anthracene glycoside, asperflavin ribofuranoside, and polyketides from a marine isolate of the fungus microsporum. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):882-3.

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