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Enclomiphene citrate

Catalog No. T7313 CAS 7599-79-3

Synonyms: Enclomifene citrate, (E)-Clomiphene citrate, trans-Clomiphene citrate

Enclomiphene citrate (trans-Clomiphene citrate) is a non-steroidal estrogen receptor antagonist,with antioestrogenic property

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Enclomiphene citrate, CAS 7599-79-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 48.00
10 mg	In stock	$ 74.00
25 mg	In stock	$ 136.00
50 mg	In stock	$ 224.00
100 mg	In stock	$ 332.00
1 mL * 10 mM (in DMSO)	In stock	$ 65.00

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Purity: 98%

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Description	Enclomiphene citrate (trans-Clomiphene citrate) is a non-steroidal estrogen receptor antagonist,with antioestrogenic property
In vivo	total testosterone (TT) levels increased between baseline and after 16 weeks of treatment in all the treatment groups. FSH and LH levels increased in the enclomiphene citrate groups and decreased in the testosterone gel group at 16 weeks. Enclomiphene citrate maintained sperm concentration in the normal range over the treatment period, while there was a marked reduction in spermatogenesis in the testosterone gel group[1].
Animal Research	Two parallel randomised, double-blind, double-dummy, placebo-controlled, multicentre, phase III studies were undertaken to evaluate two doses of enclomiphene citrate vs testosterone gel on total testosterone (TT), LH, FSH, and sperm counts in overweight men aged 18-60 years with secondary hypogonadism. Men were screened and enrolled in the trials (ZA-304 and ZA-305). All enrolled men had early morning serum TT levels in the low or low normal range (≤300 ng/dL; ≤10.4 nmol/L) and had low or normal LH (<9.4 IU/L) levels measured on two separate occasions 2-10 days apart. Serum samples were obtained over the course of the study to determine relevant hormone levels at baseline and after 16 weeks of treatment. Men provided semen samples twice to enroll at the beginning and twice at the end of the study[1].

Synonyms	Enclomifene citrate, (E)-Clomiphene citrate, trans-Clomiphene citrate
Molecular Weight	598.08
Formula	C32H36ClNO8
CAS No.	7599-79-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (83.60 mM)

References and Literature

1. Kim E D , Mccullough A , Kaminetsky J . Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement[J]. BJU International, 2016, 117(4):677-685. 2. Kovac, Jason R . Reproductive endocrinology: Oral enclomiphene citrate in obese men with hypogonadism[J]. Nature Reviews Urology, 2016.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Bioactive Compounds Library Max FDA-Approved & Pharmacopeia Drug Library Nuclear Receptor Compound Library Anti-Ovarian Cancer Compound Library Approved Drug Library

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Keywords

Enclomiphene citrate 7599-79-3 Endocrinology/Hormones Estrogen Receptor/ERR testosterone deficiency Inhibitor trans-Clomiphene testosterone Hypogonadal trans-Clomiphene Citrate hormone ovarian dysfunction Enclomifene Citrate Enclomiphene Citrate inhibit Enclomifene Clomiphene Citrate hypogonadism (E)-Clomiphene Enclomifene citrate estrogen receptor modulator Enclomiphene (E)-Clomiphene citrate trans-Clomiphene citrate inhibitor

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