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Diclofensine

Catalog No. T7341 CAS 67165-56-4

Synonyms: Ro 8-4650

Diclofensine inhibits the uptake of serotonin, noradrenaline and dopamine.

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Diclofensine, CAS 67165-56-4

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	Diclofensine inhibits the uptake of serotonin, noradrenaline and dopamine.
In vivo	A controlled trial with diclofensine, a new psychoactive drug, in the treatment of depression[1].
Animal Research	In a controlled study, out-patients suffering from moderate to severe depression were treated with the objective of assessing the new drug's therapeutically effective dose range. Maprotiline was used as a reference drug: fourteen patients were assigned to receive diclofensine and thirteen to receive maprotiline in a double-blind design. Depending on tolerance and efficacy, they were treated for periods ranging from 5 to 150 days. Doses were titrated to the optimum[1].

Synonyms	Ro 8-4650
Molecular Weight	322.2
Formula	C17H17Cl2NO
CAS No.	67165-56-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Cherpillod C , Omer L M O . A Controlled Trial with Diclofensine, a New Psychoactive Drug, in the Treatment of Depression[J]. Journal of International Medical Research, 1981, 9(5):324-329. 2. Jansen W , G W Brückner, Henauer S , et al. [Clinical double blind comparison of diclofensine and placebo in geriatric patients with depressive syndromes][J]. Pharmacopsychiatria, 1982, 15(6):205-209.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Diclofensine 67165-56-4 GPCR/G Protein Membrane transporter/Ion channel Neuroscience Dopamine Receptor Monoamine Transporter SLC6A3 Inhibitor DAT Dopamine Transporter Ro 8-4650 inhibit inhibitor

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