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Dasotraline hydrochloride

Catalog No. T3526 CAS 675126-08-6

Synonyms: SEP-225289 hydrochloride

Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that inhibits dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.

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Dasotraline hydrochloride, CAS 675126-08-6

Pack Size	Availability	Price/USD
1 mg	In stock	99.00
5 mg	In stock	333.00
10 mg	In stock	594.00
25 mg	In stock	1080.00
50 mg	Inquiry	1779.00

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Purity 99.60%

HNMR HPLC COA

Datasheet SDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that inhibits dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
Targets&IC50	5-HT , Dopamine , Norepinephrine (NE)

Synonyms	SEP-225289 hydrochloride
Purity	99.60%
Molecular Weight	328.66
Formula	C16H16Cl3N
CAS No.	675126-08-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 31 mg/mL (94.32 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Guiard BP, et al. Characterization of the electrophysiological properties of triple reuptake inhibitors on monoaminergic neurons. Int J Neuropsychopharmacol. 2011 Mar;14(2):211-23. 2. DeLorenzo C, et al. SEP-225289 serotonin and dopamine transporter occupancy: a PET study.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Inhibitor Library Anti-Cancer Compound Library Clinical Compound Library Neuronal Signaling Compound Library Serotonin Receptor-Targeted Compound Library GPCR Compound Library Drug Repurposing Compound Library Neurotransmitter Receptor Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Parkinson's Disease Compound Library

Related Products

Related compounds with same targets

Tandospirone GSK163090 Dexpramipexole Sumanirole maleate CP-809101 lumateperone Tosylate Nemifitide acetate(173240-15-8 free base) Neuromedin N acetate(92169-45-4 free base)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.