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Daidzin

Daidzin
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Purity:99.43%
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Daidzin

Catalog No. T2901Cas No. 552-66-9
Daidzin (Daidzoside) is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
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Pack SizePrice/USDAvailabilityQuantity
10 mg$37In Stock
50 mg$56In Stock
100 mg$73In Stock
500 mg$158In Stock
1 mL x 10 mM (in DMSO)$44In Stock
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Product Introduction

Bioactivity
Description
Daidzin (Daidzoside) is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
In vitro
Daidzin, a glycoside of daidzein, increases the transcriptional activity of RARα and RARγ but does not bind to the RARs[1]. Daidzin does not inhibit human class Ⅰ, Ⅱ, or Ⅲ alcohol dehydrogenases, nor does it have any significant effect on biological systems that are known to be affected by other isoflavones. Daidzin inhibits human ALDH-I and ALDH-II in a concentration-dependent manner. Daidzin inhibits both ALDH-I and ALDH-II in an apparently competitive manner with Ki values of 40 nM and 20 μM, respectively, and it inhibits ALDH-I uncompetitively with respect to NAD+. The inhibition of ALDH-I by daidzin is reversible[3].
In vivo
Daidzin has no effect on alcohol-metabolizing enzymes(i.e., ADH and ALDH) when given to rats intragastrically. Chronic daidzin administration exerts an effect on alcohol pharmacokinetics, although the effect is less pronounced than when the compound is administered concurrently with ethanol.The compound is shown to shorten sleep time if ethanol is given intragastrically, but not when given intraperitoneally, indicating absence of effect on ethanol elimination rate. Daidzin delays ethanol absorption and lessens alcohol intoxication. The compound is shown to suppress the levels of BAC(blood alcohol concentration) for the first 3 hr after alcohol ingestion in both fasted and fed rats. These effects of daidzin may in part be due to its antioxidant activity[2].
Cell Research
CV-1 cells are transfected with 100 ng ERE-Luc and 50 ng ER-RARα or ER-RARγ. Transfected cells are treated with the indicated isoflavone at 0.5, 1, 10, 50, and 100 μM for 24 h. The β-Gal activity is used to normalize luciferase activity.  (Only for Reference)
AliasNPI-031D, Daidzein 7-O-glucoside, Daidzoside, Daidzein 7-glucoside
Chemical Properties
Molecular Weight416.38
FormulaC21H20O9
Cas No.552-66-9
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 50 mg/mL (120.09 mM)
Ethanol: 4 mg/mL (9.6 mM)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.4017 mL12.0083 mL24.0165 mL120.0826 mL
5 mM0.4803 mL2.4017 mL4.8033 mL24.0165 mL
DMSO
1mg5mg10mg50mg
10 mM0.2402 mL1.2008 mL2.4017 mL12.0083 mL
20 mM0.1201 mL0.6004 mL1.2008 mL6.0041 mL
50 mM0.0480 mL0.2402 mL0.4803 mL2.4017 mL
100 mM0.0240 mL0.1201 mL0.2402 mL1.2008 mL

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