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Daidzin

Catalog No. T2901 CAS 552-66-9

Synonyms: Daidzein 7-O-glucoside, Daidzoside, NPI-031D, Daidzein 7-glucoside

Daidzin is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.

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Daidzin, CAS 552-66-9

Pack Size	Availability	Price/USD	Quantity
20 mg	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 98.20%

Purity: 98.28%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Daidzin is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
Targets&IC50	ALDH-Ⅰ:20 nM(Ki)
In vitro	Daidzin, a glycoside of daidzein, increases the transcriptional activity of RARα and RARγ but does not bind to the RARs[1]. Daidzin does not inhibit human class Ⅰ, Ⅱ, or Ⅲ alcohol dehydrogenases, nor does it have any significant effect on biological systems that are known to be affected by other isoflavones. Daidzin inhibits human ALDH-I and ALDH-II in a concentration-dependent manner. Daidzin inhibits both ALDH-I and ALDH-II in an apparently competitive manner with Ki values of 40 nM and 20 μM, respectively, and it inhibits ALDH-I uncompetitively with respect to NAD+. The inhibition of ALDH-I by daidzin is reversible[3].
In vivo	Daidzin has no effect on alcohol-metabolizing enzymes(i.e., ADH and ALDH) when given to rats intragastrically. Chronic daidzin administration exerts an effect on alcohol pharmacokinetics, although the effect is less pronounced than when the compound is administered concurrently with ethanol.The compound is shown to shorten sleep time if ethanol is given intragastrically, but not when given intraperitoneally, indicating absence of effect on ethanol elimination rate. Daidzin delays ethanol absorption and lessens alcohol intoxication. The compound is shown to suppress the levels of BAC(blood alcohol concentration) for the first 3 hr after alcohol ingestion in both fasted and fed rats. These effects of daidzin may in part be due to its antioxidant activity[2].
Cell Research	CV-1 cells are transfected with 100 ng ERE-Luc and 50 ng ER-RARα or ER-RARγ. Transfected cells are treated with the indicated isoflavone at 0.5, 1, 10, 50, and 100 μM for 24 h. The β-Gal activity is used to normalize luciferase activity.  (Only for Reference)

Synonyms	Daidzein 7-O-glucoside, Daidzoside, NPI-031D, Daidzein 7-glucoside
Molecular Weight	416.382
Formula	C21H20O9
CAS No.	552-66-9

Storage

keep away from moisture

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

DMSO: 34 mg/mL

Ethanol: 4 mg/mL (9.6 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Oh HJ, et al. Mol Cell Endocrinol. 2013, 376(1-2):107-13. 2. Xie CI, et al. Alcohol Clin Exp Res. 1994, 18(6):1443-7. 3. Keung WM, et al. Proc Natl Acad Sci U S A. 1993, 90(4):1247-51. 4. Yuan Q, Cao S, Dong Q, et al. ALDH2 Activation Inhibited Cardiac Fibroblast-to-Myofibroblast Transformation Via the TGF-β1/Smad Signaling Pathway[J]. Journal of cardiovascular pharmacology. 2019 Apr;73(4): 248-256.

Citations

1. Yuan Q, Cao S, Dong Q, et al. ALDH2 Activation Inhibited Cardiac Fibroblast-to-Myofibroblast Transformation Via the TGF-β1/Smad Signaling Pathway. Journal of cardiovascular pharmacology. 2019 Apr;73(4): 248-256.

Related compound libraries

This product is contained In the following compound libraries：

Saccharide and Glycoside Natural Product Library Cuproptosis Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Infection Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Anti-Metabolism Disease Compound Library Traditional Chinese Medicine Monomer Library Anti-Tumor Natural Product Library Bioactive Compound Library Food as Medicine Compound Library

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Keywords

Daidzin 552-66-9 Metabolism Microbiology/Virology Mitochondrial Metabolism Dehydrogenase Reverse Transcriptase Daidzein 7-O-glucoside Daidzoside Inhibitor NPI-031D Daidzein 7-glucoside inhibit inhibitor

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