Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin blocks the formation of reactive oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agent's observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer.
Description | Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin blocks the formation of reactive oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agent's observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer. |
Targets&IC50 | p300 histone acetylatransferase:25 μM |
In vitro | Curcumin induces the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling. Curcumin inhibits cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1[2]. Curcumin induces endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells[3]. |
In vivo | Chronic treatment with curcumin significantly reverses the CMS-induced behavioral abnormalities in stressed rats. Additionally, curcumin effectively inhibits cytokine gene expression at both the mRNA and the protein level and reduces the activation of NF-κB[4]. |
Cell Research | 1×104 B16-R cells are cultivated as monolayer culture for 12 hr. They were then incubated in 200 μL of RPMI, 10% FBS containing curcumin at final concentrations from 1–100 μM in 96-multiwell plates for 24-48 hr. After these incubations, cells are washed twice in PBS and 500 μl of fresh culture medium containing MTT (0.3 mg/mL) are added for colorimetric assay. (Only for Reference) |
Synonyms | 姜黄素, Turmeric yellow, Indian Saffron, Diferuloylmethane, Natural Yellow 3 |
Molecular Weight | 368.39 |
Formula | C21H20O6 |
CAS No. | 458-37-7 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 3.7 mg/mL (10 mM)
Ethanol: 1.8 mg/mL (5 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Curcumin 458-37-7 表观遗传 凋亡 其他 微生物学 细胞周期 自噬 Autophagy Epigenetic Reader Domain Ferroptosis Histone Acetyltransferase Influenza Virus Mitophagy Others Indian Saffron Natural Yellow3 HATs Diferuloylmethane Natural Yellow 3 HAT Keap1-Nrf2 inhibit Turmeric yellow Mitochondrial Autophagy Natural Yellow-3 Inhibitor inhibitor