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Curcumin

Catalog No. T1516 CAS 458-37-7

Synonyms: Diferuloylmethane, Natural Yellow 3, Indian Saffron, Turmeric yellow

Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, anti-inflammatory and antioxidant.

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Curcumin, CAS 458-37-7

Pack Size	Availability	Price/USD
25 mg	In stock	$ 30.00
50 mg	In stock	$ 38.00
100 mg	In stock	$ 50.00
200 mg	In stock	$ 57.00
500 mg	In stock	$ 88.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 98.98%

Purity: 97.51%

Purity: 95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, anti-inflammatory and antioxidant.
Targets&IC50	p300 HAT:25 μM
In vitro	METHODS: Retinoblastoma cells SO-Rb50 and Y79 were treated with Curcumin (10-50 μM) for 24 h. Cell viability was measured by CCK-8. RESULTS: Curcumin dose-dependently and significantly decreased the cell viability of SO-Rb50 and Y79 cells, with IC50s of 38.4 μM and 34.8 μM, respectively.[1] METHODS: Mouse colon cancer cells MC38 were treated with Curcumin (5-50 μM) for 48 h. Apoptosis was detected by Flow Cytometry. RESULTS: Curcumin dose-dependently induced apoptosis in MC38 cells. [2] METHODS: Human pancreatic cancer cells PANC1 were treated with Curcumin (10-80 μg/mL) for 24 h. The autophagy marker LC3 was detected by Immunofluorescence. RESULTS: The highest expression level of punctate autophagosomes was found in 40 μg/mL Curcumin-treated cells. [3]
In vivo	METHODS: To detect the anti-tumor activity in vivo, Curcumin (100-200 mg/kg) was administered by gavage every three days for three weeks to C57BL/6J mice bearing mouse colon cancer tumor MC38. RESULTS: The average tumor volume and tumor weight of mice in the Curcumin treatment group were significantly reduced, and the tumor volume and tumor weight of the 200 mg/kg treatment group were also significantly lower than those of the 100 mg/kg treatment group. [2] METHODS: To detect anti-tumor activity in vivo, Curcumin (25-50 mg/kg) was injected intraperitoneally into BALB/c mice bearing Ehrlich ascites tumor EAT once daily for ten days. RESULTS: The number of EAT cells in the peripheral tissues of the Curcumin 50 mg/kg group was significantly less than that of the tumor control group. [4]
Cell Research	1×104 B16-R cells are cultivated as monolayer culture for 12 hr. They were then incubated in 200 μL of RPMI, 10% FBS containing curcumin at final concentrations from 1–100 μM in 96-multiwell plates for 24-48 hr. After these incubations, cells are washed twice in PBS and 500 μl of fresh culture medium containing MTT (0.3 mg/mL) are added for colorimetric assay. (Only for Reference)
Source	Natural Products > Zingiberaceae > Zingiber

Synonyms	Diferuloylmethane, Natural Yellow 3, Indian Saffron, Turmeric yellow
Molecular Weight	368.3799
Formula	C21H20O6
CAS No.	458-37-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (162.88 mM)

Ethanol: 1.8 mg/mL (5 mM)

References and Literature

1. Li Y, et al. Curcumin inhibits proliferation, migration, invasion and promotes apoptosis of retinoblastoma cell lines through modulation of miR-99a and JAK/STAT pathway. BMC Cancer. 2018 Dec 10;18(1):1230. 2. Li P, et al. Curcumin selectively induces colon cancer cell apoptosis and S cell cycle arrest by regulates Rb/E2F/p53 pathway. J Mol Struct. 2022 Sep;1263:133180. 3. Zhu Y, et al. Curcumin Induces Autophagy, Apoptosis, and Cell Cycle Arrest in Human Pancreatic Cancer Cells. Evid Based Complement Alternat Med. 2017;2017:5787218. 4. Yılmaz S, et al. Investigating the anti-tumoral effect of curcumin on the mice in which Ehrlich ascites and solid tumor is created. Iran J Basic Med Sci. 2019 Apr;22(4):418-425. 5. Odot J, et al. Int J Cancer. 2004, 111(3):381-387. 6. Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system[J]. Chemistry & Biodiversity. 2021 7. Zhou H, Ning Y, Zeng G, et al. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT[J]. Oncology Reports. 2021, 45(4): 1-1. 8. Sun L, Qian S, Ma Y, et al. Iron Overload Adversely Effects Bone Marrow Haematogenesis via SIRT-SOD2-MROS in a Process Ameliorated by Curcumin[J]. Cellular & Molecular Biology Letters. 2021, 26(1): 1-15. 9. Geng W, Guo X, Zhang L, et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway[J]. Biomedicine & Pharmacotherapy. 2018 Nov;107:484-494. 10. Tian D, Cao L, Li Q, et al. Benzannulated 5, 5-spiroketal sesquiterpenes from the roots of Angelica Pubescens[J]. Bioorganic Chemistry. 2021, 107: 104604.

Citations

1. Geng W, Guo X, Zhang L, et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway .Resveratrol inhibits proliferation,migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway. Biomedicine & Pharmacotherapy. 2018 Nov;107:484-494. 2. Gou X, Tian D, Wei J, et al. New Drimane Sesquiterpenes and Polyketides from Marine-Derived Fungus Penicillium sp. TW58-16 and Their Anti-Inflammatory and α-Glucosidase Inhibitory Effects. Marine Drugs. 2021, 19(8): 416. 3. Tian D, Cao L, Li Q, et al. Benzannulated 5,5-spiroketal sesquiterpenes from the roots of Angelica Pubescens. Bioorganic Chemistry. 2021, 107: 104604 4. Liu Y P, Xie Z, Guan R Q, et al. Syzysamalactone, an Unusual 11-Carbon δ‑Lactone Derivative from the Fresh Ripe Fruits of Syzygium samarangense (Wax Apple). Journal of Natural Products. 2022 5. Sun L, Qian S, Ma Y, et al. Iron Overload Adversely Effects Bone Marrow Haematogenesis via SIRT-SOD2-MROS in a Process Ameliorated by Curcumin. Cellular & Molecular Biology Letters. 2021, 26(1): 1-15 6. Zhou H, Ning Y, Zeng G, et al. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT. Oncology Reports. 2021, 45(4): 1-1. 7. Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system. Chemistry & Biodiversity. 2021 8. Wang W, Zeng Z, Zhang J, et al.A Systematic Study of Traditional Chinese Medicine for the Treatment of Lung Adenocarcinoma Using a Reverse Network of Key Targets Based on Bioinformatics and Molecular Docking: Curcumin and Trans-Resveratrol as Potential Drug Candidates for Lung Adenocarcinoma.Natural Product Communications.2023, 18(5): 1934578X231169370. 9. Bu H, Wang B, Wu Y, et al.Curcumin strengthens a spontaneous self-protective mechanism-SP1/PRDX6 pathway, against di-n-butyl phthalate-induced testicular ferroptosis damage.Environmental Science and Pollution Research.2023: 1-17.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Antiparasitic Natural Product Library Anti-Cancer Active Compound Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Chromatin Modification Compound Library Anti-Aging Compound Library Anti-Lung Cancer Compound Library

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Keywords

Curcumin 458-37-7 Apoptosis Autophagy Chromatin/Epigenetic DNA Damage/DNA Repair Immunology/Inflammation Microbiology/Virology Mitophagy Epigenetic Reader Domain Ferroptosis Influenza Virus Histone Acetyltransferase HDAC Nrf2 Natural Yellow3 Diferuloylmethane HATs Natural Yellow 3 HAT Keap1-Nrf2 inhibit Mitochondrial Autophagy Natural Yellow-3 Indian Saffron Turmeric yellow Inhibitor inhibitor

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