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Chromatin/Epigenetic Epigenetic Reader Domain Curcumin

Curcumin

Catalog No. T1516   CAS 458-37-7
Synonyms: Diferuloylmethane, Natural Yellow 3, Turmeric yellow, Indian Saffron

Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin blocks the formation of reactive oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agent's observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer.

Curcumin, CAS 458-37-7
Pack Size Availability Price/USD Quantity
10 mg In stock 20.00
25 mg In stock 30.00
50 mg In stock 38.00
100 mg In stock 50.00
200 mg In stock 64.00
500 mg In stock 98.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Purity 97.51%
Purity 95.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin blocks the formation of reactive oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agent's observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer.
Targets&IC50 KEAP1-Nrf2 ,   p300 histone acetylatransferase
In vitro Curcumin induces the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling. Curcumin inhibits cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1[2]. Curcumin induces endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells[3].
Cell Research
1×104 B16-R cells are cultivated as monolayer culture for 12 hr. They were then incubated in 200 μL of RPMI, 10% FBS containing curcumin at final concentrations from 1–100 μM in 96-multiwell plates for 24-48 hr. After these incubations, cells are washed twice in PBS and 500 μl of fresh culture medium containing MTT (0.3 mg/mL) are added for colorimetric assay. (Only for Reference)
Cell lines: murine melanoma cell subline(B16-R)
Synonyms Diferuloylmethane , Natural Yellow 3 , Turmeric yellow , Indian Saffron
Purity 97.51%
Molecular Weight 368.39
Formula C21H20O6
CAS No. 458-37-7

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 3.7 mg/mL (10 mM)

Ethanol: 1.8 mg/mL (5 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Gao S, et al. Food Chem Toxicol. 2013, 59:739-47. 2. Nasiri M, et al. Asian Pac J Cancer Prev. 2013, 14(6):3449-3453. 3. Cao A, et al. Apoptosis. 2013, 18(11):1391-1402. 4. Jiang H, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2013, 47:33-39. 5. Odot J, et al. Int J Cancer. 2004, 111(3):381-387. 6. Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system[J]. Chemistry & Biodiversity. 2021 7. Zhou H, Ning Y, Zeng G, et al. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT[J]. Oncology Reports. 2021, 45(4): 1-1. 8. Sun L, Qian S, Ma Y, et al. Iron Overload Adversely Effects Bone Marrow Haematogenesis via SIRT-SOD2-MROS in a Process Ameliorated by Curcumin[J]. Cellular & Molecular Biology Letters. 2021, 26(1): 1-15. 9. Geng W, Guo X, Zhang L, et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway[J]. Biomedicine & Pharmacotherapy. 2018 Nov;107:484-494. 10. Tian D, Cao L, Li Q, et al. Benzannulated 5, 5-spiroketal sesquiterpenes from the roots of Angelica Pubescens[J]. Bioorganic Chemistry. 2021, 107: 104604.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Natural Compound Library for HTS Anti-cancer Compound Library Anti-infection Compound Library Apoptosis Compound Library Autophagy Compound Library Epigenetics Compound Library Human Endogenous Metabolite Compound Library Immunology/Inflammation Compound Library Selected Plant-sourced Compound Library DNA Damage & Repair Compound Library Bioactive Lipid Compound Library Polyphenolic Natural Compound Library Anti-cancer Metabolism Compound Library Histone Modification Research Compound Library NF-κB Signaling Compound Library Food as Medicine Library Anti-obesity Compound Library Anti-aging Compound Library Chromatin Modification Compound Library Antitumor Natural Products Library Natural Compoud Library in Chinese Pharmacopoeia Anti-cancer Active Compound library Target-Focused Phenotypic Screening Library Anti-Inflammatory Tradition Chinese Medicine Library Ferroptosis Compound Library Neurodegenerative disease-related Compound Library FDA Approved & Pharmacopeial Drug Library Traditional Chinese Medicine Monomer Library Anti-Alzheimer's Disease Compound Library Anti-fibrosis Compound Library

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