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Corynoline

Name: Corynoline
Brand: TargetMol
SKU: T6S2356
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S2356Cas No. 18797-79-0

Alias (+)-Corynoline

1. Corynoline ((+)-Corynoline) is an acetylcholinesterase inhibitor.

Corynoline

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Purity: 99.29%

Catalog No. T6S2356Alias (+)-CorynolineCas No. 18797-79-0

1. Corynoline ((+)-Corynoline) is an acetylcholinesterase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$47	In Stock	In Stock
10 mg	$80	In Stock	In Stock
25 mg	$153	In Stock	In Stock
50 mg	$228	In Stock	In Stock
100 mg	$345	-	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.29%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Corynoline AI Summary

Corynoline demonstrates anti-inflammatory activity by inhibiting nitric oxide production in mouse RAW264.7 cells induced by lipopolysaccharide (LPS), with an IC50 value of 2510.0 nM. This was determined using a Griess reagent-based assay after a 2-hour preincubation, followed by a 24-hour LPS challenge. Additionally, Corynoline exhibits inhibitory activity against both human MAO-A and MAO-B enzymes, showing a residual activity of around 87% at a concentration of 20 μM in spectrophotometric assays. The IC50 values for MAO-A and MAO-B inhibition were greater than 20,000.0 nM, indicating moderate potency in inhibiting these enzymes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Corynoline ((+)-Corynoline) is an acetylcholinesterase inhibitor.
Synonyms	(+)-Corynoline

Chemical Properties

Molecular Weight	367.40
Formula	C₂₁H₂₁NO₅
Cas No.	18797-79-0
Smiles	CN1Cc2c3OCOc3ccc2[C@@]2(C)[C@@H](O)Cc3cc4OCOc4cc3[C@@H]12
Relative Density.	1.396 g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 42 mg/mL (114.32 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (2.72 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7218 mL	13.6091 mL	27.2183 mL	136.0915 mL
5 mM	0.5444 mL	2.7218 mL	5.4437 mL	27.2183 mL
10 mM	0.2722 mL	1.3609 mL	2.7218 mL	13.6091 mL
20 mM	0.1361 mL	0.6805 mL	1.3609 mL	6.8046 mL
50 mM	0.0544 mL	0.2722 mL	0.5444 mL	2.7218 mL
100 mM	0.0272 mL	0.1361 mL	0.2722 mL	1.3609 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc