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Cevipabulin

Catalog No. T10772 CAS 849550-05-6

Synonyms: TTI-237

Cevipabulin (TTI-237) is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).

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Cevipabulin, CAS 849550-05-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 50.00
5 mg	In stock	$ 90.00
10 mg	In stock	$ 139.00
25 mg	In stock	$ 297.00
1 mL * 10 mM (in DMSO)	In stock	$ 107.00

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Purity: 99.53%

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Description	Cevipabulin (TTI-237) is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).
Targets&IC50	Microtubule (human tumor cells):18-40 nM
In vitro	Cevipabulin (0-50 nM, 72 hours) shows good activity (IC50s: 18~40 nM) on cell lines from ovarian, breast, prostate, and cervical tumors. Cevipabulin at low concentrations (20-40 nM) produces sub-G1 nuclei and, at concentrations above 50 nM, it causes a strong G2-M block [1].
In vivo	In mice, Cevipabulin ( 5, 10, 15, and 20 mg/kg, every 4 days for 4 cycles; i.v. and p.o.) is active against human tumor xenografts and showing dose-dependent effects, with good antitumor activity at 20 and 15 mg/kg [1].

Synonyms	TTI-237
Molecular Weight	464.82
Formula	C18H18ClF5N6O
CAS No.	849550-05-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 15.3 mg/mL (32.9 mM), Sonication is recommended.

References and Literature

1. Beyer CF, et al. TTI-237: a novel microtubule-active compound with in vivo antitumor activity. Cancer Res. 2008 Apr 1;68(7):2292-300. 2. Beyer CF, et al. The microtubule-active antitumor compound TTI-237 has both paclitaxel-like and vincristine-like properties. Cancer Chemother Pharmacol. 2009 Sep;64(4):681-9.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Cancer Drug Library Inhibitor Library Microtubule-Targeted Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Bioactive Compound Library Cytoskeletal Signaling Pathway Compound Library Clinical Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

ABT-751 Plinabulin Vinblastine KIF18A-IN-2 Combretastatin A4 Myoseverin Ansamitocin p-3 Verubulin hydrochloride

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Keywords

Cevipabulin 849550-05-6 Cytoskeletal Signaling Microtubule Associated TTI 237 TTI-237 TTI237 inhibitor inhibit

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