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CPI-360

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Purity:99.52%

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COA HPLC HNMR

CPI-360

Catalog No. T6810Cas No. 1802175-06-9

CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.

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Pack Size	Price	Availability
1 mg	$76	In Stock
5 mg	$175	In Stock
10 mg	$285	In Stock
25 mg	$478	In Stock
50 mg	$687	In Stock
100 mg	$998	In Stock

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Product Introduction

Bioactivity

Description	CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.
In vitro	In KARPAS-422 cells, CPI-360 potently reduces global H3K27me3 and H3K27me2 levels with EC50 of 56 nM and 65 nM, respectively. CPI-360 also causes time-dependent transcriptional changes, and affects the viability of Y641N mutant EZH2-containing KARPAS-422 cells. In addition, CPI-360 gradually arrests KARPAS-422 cells in the G1 cell cycle stage followed by the induction of apoptosis. [1]
In vivo	In mice bearing KARPAS-422 xenografts, CPI-360 (200 mg/kg, s.c.) reduces tumor growth by 44%. [1]
Alias	Synonym 2, CPI 360, CPI360

Chemical Properties

Molecular Weight	437.53
Formula	C25H31N3O4
Cas No.	1802175-06-9

Storage & Solubility Information

Storage

|Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (51.4 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMF: 9.0 mg/mL (20.6 mM)

Ethanol: 27.0 mg/mL (61.7 mM)

Solution Preparation Table

Ethanol/DMF

	1mg	5mg	10mg	50mg
1 mM	2.2856 mL	11.4278 mL	22.8556 mL	114.2779 mL
5 mM	0.4571 mL	2.2856 mL	4.5711 mL	22.8556 mL
10 mM	0.2286 mL	1.1428 mL	2.2856 mL	11.4278 mL
20 mM	0.1143 mL	0.5714 mL	1.1428 mL	5.7139 mL

Ethanol

	1mg	5mg	10mg	50mg
50 mM	0.0457 mL	0.2286 mL	0.4571 mL	2.2856 mL
100 mM	0.0229 mL	0.1143 mL	0.2286 mL	1.1428 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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