Powder: -20°C for 3 years
In solvent: -80°C for 2 years
CK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 µM, 11.9 µM, and 15.25 µM).
Description | CK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 µM, 11.9 µM, and 15.25 µM). |
Targets&IC50 | Apoptosis:, Pim1:8.65 μM (ki), CK2:0.25 μM (ki), CK2:0.5 μM, HIPK2:15.25 μM (ki), DYRK1A:11.9 μM (ki), ERK8:0.5 μM |
In vitro | In Jurkat cells, CK2/ERK8-IN-1 (Compound K66; 0-50 µM; 24 hours) treatment displays cytotoxic activity[1]. |
Molecular Weight | 534.82 |
Formula | C11H9Br4N3O2 |
CAS No. | 1085822-09-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 16 mg/mL (29.9 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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CK2/ERK8-IN-1 1085822-09-8 代谢 干细胞 Casein Kinase TMCB Inhibitor inhibitor inhibit