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CK2/ERK8-IN-1

Catalog No. T10827 CAS 1085822-09-8

CK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 µM, 11.9 µM, and 15.25 µM).

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CK2/ERK8-IN-1, CAS 1085822-09-8

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Purity: 98%

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Description	CK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 µM, 11.9 µM, and 15.25 µM).
Targets&IC50	Apoptosis:, Pim1:8.65 μM (ki), CK2:0.25 μM (ki), CK2:0.5 μM, HIPK2:15.25 μM (ki), DYRK1A:11.9 μM (ki), ERK8:0.5 μM
In vitro	In Jurkat cells, CK2/ERK8-IN-1 (Compound K66; 0-50 µM; 24 hours) treatment displays cytotoxic activity[1].

Molecular Weight	534.82
Formula	C11H9Br4N3O2
CAS No.	1085822-09-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 16 mg/mL (29.9 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Pagano MA, et al. The selectivity of inhibitors of protein kinase CK2: an update. Biochem J. 2008 Nov 1;415(3):353-65.

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Keywords

CK2/ERK8-IN-1 1085822-09-8 代谢干细胞 Casein Kinase TMCB Inhibitor inhibitor inhibit

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