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Bromocriptine mesylate

Catalog No. T5842 CAS 22260-51-1

Synonyms: CB-154

Bromocriptine mesylate (CB-154) is a potent dopamine receptor agonist that binds the D2 receptor with highest affinity (Ki = 2.5 nM)

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Bromocriptine mesylate Chemical Structure

Bromocriptine mesylate, CAS 22260-51-1

Pack Size	Availability	Price/USD	Quantity
100 mg	In stock	$ 59.00
1 mL * 10 mM (in DMSO)	In stock	$ 55.00

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Purity: 99.87%

Purity: 99.85%

Purity: 99.83%

Purity: 99.76%

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Storage & Solubility Information

Description	Bromocriptine mesylate (CB-154) is a potent dopamine receptor agonist that binds the D2 receptor with highest affinity (Ki = 2.5 nM)
Targets&IC50	D2:2.5 nM(ki)
In vitro	The ergot alkaloid bromocriptine (BKT) was found to act as a strong inhibitor of purified neuronal nitric oxide synthase (NOS) (IC50 = 10 +/- 2 microM) whereas it was poorly active towards inducible macrophage NOS (IC50 > 100 microM). BKT affects the activation of NOS by calmodulin, as it not only inhibits L-arginine oxidation to NO and L-citrulline but also NADPH oxidation and calmodulin-dependent cytochrome c reduction catalyzed by neuronal NOS. These results suggest that BKT could exert some of its therapeutic effects by interfering with the NOS-dependent formation of nitric oxide and/or superoxide ion in various tissues.

Synonyms	CB-154
Molecular Weight	750.7
Formula	C33H44BrN5O8S
CAS No.	22260-51-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (39.96 mM)

References and Literature

1. Renodon A , Boucher J L , Sari M A , et al. Bromocriptine is a strong inhibitor of brain nitric oxide synthase: possible consequences for the origin of its therapeutic effects[J]. 1997, 406(1-2):0-36. 2. Zhuang Y, Xu P, Mao C, et al. Structural insights into the human D1 and D2 dopamine receptor signaling complexes[J]. Cell. 2021

Citations

1. Zhuang Y, Xu P, Mao C, et al. Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell. 2021, 184(4): 931-942. e18.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library GPCR Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Approved Drug Library Membrane Protein-targeted Compound Library Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library FDA-Approved Drug Library

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Dopamine D2 receptor agonist-2 Trimipramine maleate Clebopride malate Mesoridazine Besylate Promethazine Pipamperone 5-HT1A modulator 1 9-FLUORENOL

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Keywords

Bromocriptine mesylate 22260-51-1 Autophagy GPCR/G Protein Neuroscience Dopamine Receptor Bromocriptine Mesylate Bromocriptine CB 154 Inhibitor inhibit CB-154 CB154 inhibitor

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