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Britannilactone diacetate

Catalog No. TN2511 CAS 1286694-67-4

Synonyms: 1,6-O,O-Diacetylbritannilactone

1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic activity, it reduces leukotriene C4 production and degranulation through the suppression of cytosolic Phospholipase A2 phosphorylation and Phospholipase Cγ-mediated Ca2+ influx in IgE/antigen-stimulated BMMCs. OODBL also exhibits potent antitumor activity against several human cancer cell lines.

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Britannilactone diacetate, CAS 1286694-67-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic activity, it reduces leukotriene C4 production and degranulation through the suppression of cytosolic phospholipase A2 phosphorylation and phospholipase Cγ-mediated Ca2+ influx in IgE/antigen-stimulated BMMCs. OODBL also exhibits potent antitumor activity against several human cancer cell lines.

Synonyms	1,6-O,O-Diacetylbritannilactone
Molecular Weight	350.41
Formula	C19H26O6
CAS No.	1286694-67-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Britannilactone diacetate 1286694-67-4 Angiogenesis Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair Immunology/Inflammation JAK/STAT signaling MAPK Proteases/Proteasome Stem Cells Caspase ROS IL Receptor PARP JNK STAT JAK 1,6-O,O-Diacetylbritannilactone Inhibitor inhibitor inhibit

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