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Bismuth Subcitrate Potassium

Catalog No. T6415 CAS 880149-29-1

Bismuth Subcitrate is an antibiotic used to treat stomach ulcers associated with Helicobacter pylori, a bacterial infection.

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Bismuth Subcitrate Potassium Chemical Structure

Bismuth Subcitrate Potassium, CAS 880149-29-1

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bismuth Subcitrate is an antibiotic used to treat stomach ulcers associated with Helicobacter pylori, a bacterial infection.
Targets&IC50	C. pyloridis:8 ug/ml (MIC50)
In vitro	Colloidal Bismuth Subcitrate is crystallized in dilute HCl at pH 3, and unique assembly of three basic bismuth citrate dimeric units ([Bi(cit)2Bi]2-) leads to the formation of two-dimensional sheets and 3D polymer, the solubility of Colloidal Bismuth Subcitrate in water is found to be dramatically affected by pH, from >70 mg/mL at pH 7 to only about 1 mg/mL at pH 3. [1] Bismuth Subcitrate is effective against the 12 C. pyloridis strains with MIC50 of 8 μg/mL. Bismuth Subcitrate combined with oxolinic acid exhibits synergistic activity against the 12 C. pyloridis strains. [2] Colloidal bismuth subcitrate (5 mg/mL) significantly increases the frequencies of sister-chromatid exchange (SCE) and micronucleus rate in peripheral lymphocytes compared with controls in human whole blood cultures. [3] Bismuth Subcitrate (100 μM) inhibits Helicobacter pyloriF1-ATPase activity, and inhibition is prevented and reversed by the mercaptan glutathione, indicating that Bismuth Subcitrate interfere with sulfhydryl groups of the enzyme. [4] Colloidal Bismuth Subcitrate (150 mg/mL) inhibits the lipolytic activity of C. pylori filtrate, causing a 21% reduction in lipase activity and a 60% reduction in the activity of phospholipase A. [5]

Molecular Weight	782.67
Formula	C12H10BiK5O14+2
CAS No.	880149-29-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 127.8 mM

References and Literature

1. Tsuji A, et al. Pharm Res, 1994, 11(1), 30-37. 2. Van Caekenberghe DL, et al. Antimicrob Agents Chemother, 1987, 31(9), 1429-1430. 3. Geyikoglu F, et al. Toxicol Ind Health, 2007, 23(8), 487-492. 4. Beil W, et al. Pharmacology, 1995, 50(5), 333-337. 5. Slomiany BL, et al. Am J Gastroenterol, 1989, 84(10), 1273-1277.

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Keywords

Bismuth Subcitrate Potassium 880149-29-1 Microbiology/Virology Others Antibiotic Antibacterial inhibit Inhibitor Bismuth subcitrate Bacterial inhibitor

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