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Alvelestat

Name: Alvelestat
Brand: TargetMol
SKU: T3107
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3107Cas No. 848141-11-7

Alias AZD9668, Avelestat

Alvelestat (AZD9668) is an orally bioavailable, selective, and reversible inhibitor of human neutrophil elastase (NE), exhibiting potential anti-inflammatory activity.

Alvelestat

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Purity: 99.45%

Catalog No. T3107Alias AZD9668, AvelestatCas No. 848141-11-7

Alvelestat (AZD9668) is an orally bioavailable, selective, and reversible inhibitor of human neutrophil elastase (NE), exhibiting potential anti-inflammatory activity.

Pack Size	Price	Availability
1 mg	$30	In Stock
2 mg	$38	In Stock
5 mg	$54	In Stock
10 mg	$81	In Stock
25 mg	$159	In Stock
50 mg	$243	In Stock
100 mg	$387	In Stock
500 mg	$923	In Stock
1 mL x 10 mM (in DMSO)	$72	In Stock

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Purity:99.45%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Alvelestat (AZD9668) is an orally bioavailable, selective, and reversible inhibitor of human neutrophil elastase (NE), exhibiting potential anti-inflammatory activity.
Targets&IC50	Neutrophil elastase:12 nM, Neutrophil elastase:9.4 nM(Ki)
In vitro	In a mouse model of (smoke)-induced airway inflammation, AZD9668 significantly reduced the number of (neutrophils) in the bronchoalveolar lavage (BAL) and the level of BAL IL-1β. Oral administration of AZD9668 in both mice and rats was able to inhibit (NE)-induced lung injury.
In vivo	In whole blood stimulated by yeast polysaccharide, AZD9668 effectively inhibits NE (NE) activity in the supernatant of antigen-challenged cells and on the surface of stimulated polymorphonuclear cells.
Synonyms	AZD9668, Avelestat

Chemical Properties

Molecular Weight	545.53
Formula	C₂₅H₂₂F₃N₅O₄S
Cas No.	848141-11-7
Smiles	Cc1c(cc(C(=O)NCc2ccc(cn2)S(C)(=O)=O)c(=O)n1-c1cccc(c1)C(F)(F)F)-c1ccnn1C
Relative Density.	1.42 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 40 mg/mL (73.32 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8331 mL	9.1654 mL	18.3308 mL	91.6540 mL
5 mM	0.3666 mL	1.8331 mL	3.6662 mL	18.3308 mL
10 mM	0.1833 mL	0.9165 mL	1.8331 mL	9.1654 mL
20 mM	0.0917 mL	0.4583 mL	0.9165 mL	4.5827 mL
50 mM	0.0367 mL	0.1833 mL	0.3666 mL	1.8331 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc