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Acetylcholine iodide

Catalog No. T6751 CAS 2260-50-6

Synonyms: Acetylcolina

Acetylcholine iodide (Acetylcolina) is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.

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Acetylcholine iodide, CAS 2260-50-6

Pack Size	Availability	Price/USD
100 mg	In stock	$ 41.00
200 mg	In stock	$ 58.00
500 mg	In stock	$ 93.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.86%

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Storage & Solubility Information

Description	Acetylcholine iodide (Acetylcolina) is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
In vitro	Acetylcholine iodide (Ach) stimulated SBC3 cell proliferation, adhesion and migration toward fibronectin (Fn) in a dose-dependent manner[1]. ACh ameliorates TNF-α-induced calpain activation by decreasing p38-MAPK phosphorylation and enhancing calpastatin expression. It elicits an anti-apoptotic effect through the activation of the muscarinic ACh receptor (MAChR) and the activation of anti-oxidant systems. ACh increases cell viability and decreases TNF-α-induced apoptosis in H9c2 cells[2].
In vivo	Acetylcholine can inhibit pro-inflammatory cytokine release and protect against cardiomyocyte injury[2].
Cell Research	The SBC3 cells are seeded at 2000 cells/well in treated 96-well plates maintained with RPMI1640 medium containing 10% (v/v) FCS for 24 h. The medium is removed and replaced with 100 μl RPMI1640 containing 1% (v/v) ITS. The cells are incubated in serum free medium for 24 h to synchronize the cell cycle. Then another 100 μl serum-free medium containing the agonist/antagonist under investigation is added. The antagonist is added 30 min before Ach(Acetylcholine iodide). At this time, the cells in a duplicate plate are given 100 μl serum-free medium and a MTT assay is used to determine live cell numbers before treatment with the agonist/antagonist as measured by the absorbance (OD) at 550 nm/650 nm. After 24, 48 or 72 h culture, the remaining cells are assayed to yield post-agonist/antagonist cell numbers using the same method. All the experiments are performed in triplicate.(Only for Reference)

Synonyms	Acetylcolina
Molecular Weight	273.11
Formula	C7H16NO2·I
CAS No.	2260-50-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (183.08 mM)

H2O: 33 mg/mL (120.83 mM)

References and Literature

1. Zhang S, et al. Anticancer Res. 2010, 30(1):97-106. 2. Zhao M, et al. Cell Physiol Biochem. 2015, 36(5):1877-89.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Tumor Natural Product Library Natural Product Library RO5 Drug-like Natural Product Library FDA-Approved & Pharmacopeia Drug Library Natural Product Library for HTS Bioactive Compound Library Approved Drug Library Bioactive Compounds Library Max FDA-Approved Drug Library

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Keywords

Acetylcholine iodide 2260-50-6 Others Acetylcolina ACh Inhibitor Acetylcholine Iodide Acetylcholine inhibit inhibitor

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