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3-Amino-1,2,4-triazole

Catalog No. T67498 CAS 61-82-5

Synonyms: Amitrole, 3-AT, 1H-1,2,4-Triazol-5-amine, Trapidil impurity B

3-Amino-1,2,4-triazole (Trapidil impurity B) is an inhibitor of catalase, capable of inducing the compensatory mechanism for hydrogen peroxide detoxification. This mechanism involves increasing the activities of glutathione peroxidase and glutathione reductase.

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3-Amino-1,2,4-triazole Chemical Structure

3-Amino-1,2,4-triazole, CAS 61-82-5

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10 g	5 days	$ 41.00

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Purity: 97.16%

Biological Description

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Description

In vitro

Amitrole (1,10 and 100 microg/ml ) had no significant cytotoxicity to the FRTL-5 cells (P > 0.05). The concentration of thyroglobulin (TG) in the culture was decreased by 10 and 100 microg/ml amitrole (P < 0.05), and the concentration of TG in the cells was decreased by 100 microg/ml (P < 0.05) but the TTF-1 in the cells were not obviously changed (P > 0.05). The TSHR in the surface of FRTL-5 cells was significantly decreased by all doses of amitrole (P < 0.01). The influence of amitrole on TG of FRTL-5 cells may be related to significantly reduce TSHR in the surface of FRTL-5 cells.[1]

Synonyms	Amitrole, 3-AT, 1H-1,2,4-Triazol-5-amine, Trapidil impurity B
Molecular Weight	84.08
Formula	C2H4N4
CAS No.	61-82-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (1070.4 mM), Sonication is recommended.

References and Literature

1. Pan H, et al. Mechanism of the effects of amitrole on the thyroglobulin in Fischer rat thyroid follicle-5 cell. Wei Sheng Yan Jiu. 2011;40(4):434-440. 2. Pan HM, et al. Effects of amitrole on thyroid hormone-associated gene transcription in FRTL-5 cells. Nan Fang Yi Ke Da Xue Xue Bao. 2008;28(1):12-15. 3. Furukawa A, et al. Oxidatively generated DNA damage induced by 3-amino-5-mercapto-1,2,4-triazole, a metabolite of carcinogenic amitrole. Mutat Res. 2010;694(1-2):7-12. 4. La Rocca N, et al. Amitrole treatment of etiolated barley seedlings leads to deregulation of tetrapyrrole synthesis and to reduced expression of Lhc and RbcS genes. Planta. 2001;213(1):101-108.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Cancer Compound Library

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Keywords

3-Amino-1,2,4-triazole 61-82-5 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species Amitrole 3-AT 1H-1,2,4-Triazol-5-amine Trapidil impurity B inhibitor inhibit

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