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1-Deoxymannojirimycin hydrochloride

Catalog No. T22468 CAS 73465-43-7

1-Deoxymannojirimycin hydrochloride is a selective α1,2-mannosidase inhibitor(IC50: 20 μM). 1-Deoxymannojirimycin hydrochloride also inhibits HIV‐1 strains and has poor antiviral activity.

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1-Deoxymannojirimycin hydrochloride Chemical Structure

1-Deoxymannojirimycin hydrochloride, CAS 73465-43-7

Pack Size	Availability	Price/USD
1 mg	35 days	$ 68.00
5 mg	35 days	$ 210.00
10 mg	35 days	$ 315.00
25 mg	35 days	$ 525.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	1-Deoxymannojirimycin hydrochloride is a selective α1,2-mannosidase inhibitor(IC50: 20 μM). 1-Deoxymannojirimycin hydrochloride also inhibits HIV‐1 strains and has poor antiviral activity.
Targets&IC50	α1/2 mannosidase I:20 μM
In vitro	Exposure of such mutant virus strains to 1-Deoxymannojirimycin results in an enhanced suppression of mutant virus-induced cytopathicity in CEM cell cultures[1].When combined with CBAs at concentrations that showed poor if any suppression of mutant virus replication as single drugs, a synergistic antiviral activity of 1-Deoxymannojirimycin was observed[1].

Molecular Weight	199.63
Formula	C6H14ClNO4
CAS No.	73465-43-7

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/ml(100.19 mM)

H2O: 20 mg/ml(100.19 mM)

References and Literature

1. Jan Balzarini, et al. The alpha(1,2)-mannosidase I Inhibitor 1-deoxymannojirimycin Potentiates the Antiviral Activity of Carbohydrate-Binding Agents Against Wild-Type and Mutant HIV-1 Strains Containing Glycan Deletions in gp120. FEBS Lett. 2007 May 15;581(10):2060-4. 2. F Vallee, et al. Structural Basis for Catalysis and Inhibition of N-glycan Processing Class I Alpha 1,2-mannosidases. J Biol Chem. 2000 Dec 29;275(52):41287-98.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

1-Deoxymannojirimycin hydrochloride 73465-43-7 Microbiology/Virology Others Proteases/Proteasome HIV Protease Influenza Virus 1 Deoxymannojirimycin hydrochloride HIV-1 inhibit glycosylation antiviral reticulum HIV α1,2-mannosidase Human immunodeficiency virus N-linked 1-Deoxymannojirimycin Hydrochloride Inhibitor 1Deoxymannojirimycin hydrochloride 1-Deoxymannojirimycin Endoplasmic inhibitor

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