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(S)-ATPO (Synonyms: ATPO)

Name: (S)-ATPO
Brand: TargetMol
SKU: T3473
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T3473 Copy Product Info

Purity: 99.41%

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(S)-ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.

(S)-ATPO

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Catalog No. T3473

Synonyms ATPO

(S)-ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.

Cas No. 252930-37-3

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Pack Size	Price	USA Stock	Global Stock
1 mg	$30	In Stock	In Stock
5 mg	$59	In Stock	In Stock
10 mg	$95	In Stock	In Stock
25 mg	$181	In Stock	In Stock
50 mg	$283	In Stock	In Stock
100 mg	$413	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$73	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.41%

Color:White

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Product Introduction

(S)-ATPO AI Summary

(S)-ATPO shows diverse bioactivity across multiple targets. It functions as an inhibitor of the Ionotropic glutamate receptor AMPA, demonstrating IC50 values of 35,000 nM for [3H]AMPA binding and 5,700 nM for [3H]CNQX binding. It also inhibits AMPA-induced electrophysiological responses in rat cortical slices with an IC50 value of 28,000 nM, but does not significantly inhibit [3H]CPP binding to the NMDA receptor or [3H]KAIN binding to the Ionotropic glutamate receptor kainate (IC50 > 100,000 nM). Additionally, (S)-ATPO inhibits several enzymes and pathways: Cruzain (158.5 nM), Bloom's syndrome helicase (BLM) (79.4 nM), Histone Lysine Methyltransferase G9a in various assays (50,118.7 nM, 8,912.5 nM, 5,323.3 nM), Pin1 (37,933.0 nM), and Human Flap endonuclease 1 (FEN1) (8,436.8 nM). It also inhibits Plasmodium falciparum (17,782.8 nM), Marburg Virus binding/entry (16,353.5 nM), and Human Apurinic/apyrimidinic Endonuclease 1 (APE1) (50,118.7 nM). Moreover, it enhances Arylsulfatase A (ASA1) (4,256.2 nM and 67.5 nM in different assays) and identifies Gametocytocidal compounds (6,309.6 nM)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(S)-ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.
Synonyms	ATPO

Chemical Properties

Molecular Weight	322.25
Formula	C₁₁H₁₉N₂O₇P
Cas No.	252930-37-3
Smiles	CC(C)(C)c1onc(OCP(O)(O)=O)c1C[C@H](N)C(O)=O
Relative Density.	1.443 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 3.23 mg/mL (10.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1032 mL	15.5159 mL	31.0318 mL	155.1590 mL
5 mM	0.6206 mL	3.1032 mL	6.2064 mL	31.0318 mL
10 mM	0.3103 mL	1.5516 mL	3.1032 mL	15.5159 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc