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(Z)-SU4312

Catalog No. T5676 CAS 90828-16-3

(Z)-SU4312 is a inhibitor of MAO-B and NOS(IC50 value of 0.2 μM, 19.0μM,respectively).

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(Z)-SU4312, CAS 90828-16-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 133.00
2 mg	In stock	$ 198.00
5 mg	In stock	$ 297.00
10 mg	In stock	$ 452.00
25 mg	In stock	$ 745.00
50 mg	In stock	$ 1,050.00
100 mg	In stock	$ 1,390.00
1 mL * 10 mM (in DMSO)	In stock	$ 283.00

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Purity: 99.84%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	(Z)-SU4312 is a inhibitor of MAO-B and NOS(IC50 value of 0.2 μM, 19.0μM,respectively).
Targets&IC50	MAO-B:0.2μM
In vitro	(Z)-SU4312 unexpectedly prevented MPP(+) -induced neuronal apoptosis in vitro and decreased MPTP-induced loss of dopaminergic neurons, reduced expression of mRNA for tyrosine hydroxylase and impaired swimming behaviour in zebrafish.?(Z)-SU4312 exhibited non-competitive inhibition of purified neuronal NOS (nNOS) with an IC(50) value of 19.0?μM but showed little or no effects on inducible and endothelial NOS. Molecular docking simulations suggested an interaction between (Z)-SU4312 and the haem group within the active centre of nNOS[1].
In vivo	(Z)-SU4312 was able to selectively inhibit monoamine oxidase-B (MAO-B) activity both in vitro and in vivo, with an IC50 value of 0.2 μM.(Z)-SU43122 provides therapeutic benefits in cellular and animal models of PD, possibly through multiple mechanisms including enhancement of MEF2D through the activation of PI3-K/Akt pathway, maintenance of mitochondrial biogenesis and inhibition of MAO-B activity.?(Z)-SU4312 thus may be an effective drug candidate for the prevention or even modification of the pathological processes of PD[2].
Animal Research	MPP(+) -treated neurons and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated zebrafish were used to study neuroprotection by?(Z)-SU4312. NOS activity was assayed in vitro to examine direct interactions between?SU4312?and NOS isoforms[1].

Molecular Weight	264.32
Formula	C17H16N2O
CAS No.	90828-16-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (113.5 mM)

References and Literature

1. Cui W, Zhang Z, Li W , et al. The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS[J].Br J Pharmacol. 2013 Mar;168(5):1201-14. 2. Guo B , Hu S , Zheng C , et al. Substantial protection against MPTP-associated Parkinson\"s neurotoxicity, in vitro, and, in vivo, by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B[J]. Neuropharmacology, 2017:S0028390817303817.

Citations

1. Li X W, Yuan S C, Wang M, et al.Rosmarinic acid ameliorates autoimmune responses through suppression of intracellular nucleic acid-mediated type I interferon expression.Biochemical and Biophysical Research Communications.2023

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Inhibitor Library Nonsteroidal Anti-Inflammatory Compound Library Mitochondria-Targeted Compound Library Anti-Metabolism Disease Compound Library Anti-Parkinson's Disease Compound Library Neuronal Signaling Compound Library Covalent Inhibitor Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Keywords

(Z)-SU4312 90828-16-3 Immunology/Inflammation Metabolism Neuroscience MAO NOS (Z)-SU-4312 (Z)SU4312 SU4312 SU 4312 SU-4312 (Z) SU4312 inhibitor inhibit

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