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(R)-(+)-Bay-K-8644

Catalog No. TQ0145   CAS 98791-67-4
Synonyms: (R)-(+)-Bay K 8644

(R)-(+)-Bay-K-8644 is a Ca2+ channel agonist, a dihydropyridine agonist that inhibits Ba2+ currents (IBa), induces central respiratory depression in cats, and inhibits platelet activation through competitive antagonism of thromboxane A2-prostaglandin H2 receptors.

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(R)-(+)-Bay-K-8644 Chemical Structure
(R)-(+)-Bay-K-8644, CAS 98791-67-4
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2 mg In stock $ 94.00
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Purity: 96.51%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description (R)-(+)-Bay-K-8644 is a Ca2+ channel agonist, a dihydropyridine agonist that inhibits Ba2+ currents (IBa), induces central respiratory depression in cats, and inhibits platelet activation through competitive antagonism of thromboxane A2-prostaglandin H2 receptors.
Targets&IC50 Iba:957 nM
In vitro (R)-(+)-Bay-K-8644, a commonly used L-type Ca2+ channel agonist, is actually a racemic mixture of Bay K 8644. Interestingly, each optical isomer of this compound has opposite effects on Ba2+ currents (IBa), with (R)-(+)-Bay-K-8644 acting as an antagonist and S(-)-Bay K 8644 as an agonist.Specifically, (R)-(+)-Bay-K-8644 functions as an inhibitor of Ba2+ currents (IBa) with an IC50 of 975 nM. When applied at a concentration of 0.5 μM, (R)-(+)-Bay-K-8644 suppresses IBa to 71±10% of the control level. This indicates that (R)-(+)-Bay-K-8644 acts as an effective inhibitor of Ba2+ currents in experimental settings.It's worth noting that (R)-(+)-Bay-K-8644 is classified as a calcium channel inhibitor, further emphasizing its role in modulating calcium channel activity [2].
Synonyms (R)-(+)-Bay K 8644
Molecular Weight 356.3
Formula C16H15F3N2O4
CAS No. 98791-67-4

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (280.66 mM)

TargetMolReferences and Literature

1. Sidaway P, et al. L-type Ca2+ channel sparklets revealed by TIRF microscopy in mouse urinary bladder smooth muscle. PLoS One. 2014 Apr 3;9(4):e93803. 2. Zhu HL, et al. Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba(2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):609-15.

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Keywords

(R)-(+)-Bay-K-8644 98791-67-4 DNA Damage/DNA Repair Membrane transporter/Ion channel Metabolism Calcium Channel PPAR (R)(+)BayK8644 (R) (+) Bay K 8644 Bay K8644 Bay-K 8644 (R)-(+)-Bay K 8644 Bay K 8644 Bay-K8644 Bay-K-8644 Bay K-8644 inhibitor inhibit

 

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