PKC

Protein kinase C, commonly abbreviated to PKC, is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades.

Cat. No.	Product name	CAS No.	Purity
T6S0052	Chelerythrine	34316-15-9	98.86%
T6S0052	1. Chelerythrine may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. C...
T6313	Go 6983	133053-19-7	98.84%
T6313	Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.
T26019	R59949	120166-69-0	98.82%
T26019	R59949 is used as a Diacylglycerol kinase (DGK) inhibitor.
T8764	PKC-iota inhibitor 1	2328094-11-5	98.82%
T8764	PKC-iota inhibitor 1 is an inhibitor of protein kinase C-iota (PKC-ι ; IC50 : 0.34 μM)
T3419	Chelerythrine chloride	3895-92-9	98.78%
T3419	Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to ...
TP1956L	PKC ζ pseudosubstrate acetate	TP1956L	98.78%
TP1956L	PKC ζ pseudosubstrate acetate is an inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amin...
T0158	Mitoxantrone dihydrochloride	70476-82-3	98.63%
T0158	Mitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase ...
T77628	Bisindolylmaleimide III	137592-43-9	98.6%
T77628	Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC).Bisindolylmaleimide III selectively interacts with PKCα or ribosomal S6 pro...
T6280	Enzastaurin	170364-57-5	98.52%
T6280	Enzastaurin (LY317615) is an effective PKCβ selective inhibitor (IC50: 6 nM), 6- to 20-fold selectivity against PKCα/γ/ε.
T0228	Methyl-Hesperidin	11013-97-1	98.51%
T0228	Methyl Hesperidin, a flavanone glycoside (flavonoid) (C28H34O15), is abundant in citrus fruits. Its aglycone form is called hesperetin.
T1648	α-Vitamin E	59-02-9	98.5%
T1648	(+)-α-Tocopherol is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
T10550	Bisindolylmaleimide X hydrochloride	145317-11-9	98.5%
T10550	Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).
T14989	CMPD101	865608-11-3	98.34%
T14989	CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits ...
T3684	CP21R7	125314-13-8	98.21%
T3684	CP21R7 is an effective and specific GSK3β inhibitor. It is used as an activator of stem cells prior to the induction of differentiation of stem cells to smooth m...
T7659	Bisindolylmaleimide IV	119139-23-0	98.2%
T7659	Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 μM)
T10980	DCPLA-ME	56687-67-3	98.16%
T10980	DCPLA-ME is the methyl ester form of DCPLA and can be used to treat neurodegenerative diseases. It is an effective PKCε activator.
T9605	Sangivamycin	18417-89-5	98.11%
T9605	Sangivamycin is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers...
T39030	HBDDE	154675-18-0	98.03%
T39030	HBDDE is a selective model inhibitor of the isoenzymes PKCα and PKCγ with IC 50 s of 43 μM and 50 μM, respectively.HBDDE has a higher affinity for PKCα/PKCγ than...
T17148	TPPB	497259-23-1	98.00%
T17148	TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).
T5891	D-ERYTHRO-SPHINGOSINE	123-78-4	98.00%
T5891	D-erythro-Sphingosine (trans-4-Sphingenine) is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator