Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 163.00 | |
5 mg | In stock | $ 547.00 | |
10 mg | In stock | $ 828.00 | |
25 mg | In stock | $ 1,230.00 | |
50 mg | Inquiry | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 673.00 |
Description | TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM). |
Targets&IC50 | PKC:11.9 nM (ki) |
In vitro | TPPB inhibits the activation of caspase-3 induced by Aβ25-35. TPPB could increase the phosphorylation of Akt, PKC, MARCKS, and MAPK, which are inhibited by Aβ25-35 treatment. TPPB at a concentration of 1 μM could antagonize Aβ25-35 induced cell damage. By the use of a cell line derived from an Alzheimer’s disease patient, significant enhancement of sAPPα secretion is achieved at 1 μM concentration for TPPB. TPPB has a role against Aβ25-35-induced neurotoxicity in PC12 cells [1][2]. |
In vivo | TPPB is evaluated for the induction of hyperplasia displays a modest response at 300 μg after topical application to the shaved backs of outbred Sencar mice and [1]. |
Molecular Weight | 501.54 |
Formula | C27H30F3N3O3 |
CAS No. | 497259-23-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (249.23 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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TPPB 497259-23-1 Chromatin/Epigenetic Cytoskeletal Signaling PKC Protein kinase C inhibit Inhibitor inhibitor