Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat. No.	Product name	CAS No.	Purity
T7882	Indomethacin farnesil	85801-02-1	99.84%
T7882	Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug (...
T0097L	Pazopanib	444731-52-6	99.84%
T0097L	Pazopanib (GW786034), a small molecule inhibitor, inhibits multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibi...
T0458	Indomethacin	53-86-1	99.84%
T0458	Indomethacin (Indometacin) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor.
T1795	Carfilzomib	868540-17-4	99.84%
T1795	Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome. Carfilzomib has antitumor activity and may be u...
T0087L	Sulfacetamide sodium	127-56-0	99.84%
T0087L	Sulfacetamide sodium (Sulamyd sodium) is an anti-infective agent. It is used topically to treat orally for urinary tract infections and skin infections.
T1606	Fasudil	103745-39-7	99.84%
T1606	Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T4121	Bicyclol	118159-48-1	99.84%
T4121	Bicyclol (SY801)(SY 801) is an anti-hepatitis drug. Oral administration of bicyclol normalizes the elevated serum transaminases (ALT, AST) by 50% in chronic vira...
T2754	Oxymatrine	16837-52-8	99.84%
T2754	Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment a...
T6450	Clinofibrate	30299-08-2	99.84%
T6450	Clinofibrate (Lipoclin)(IC50 of 0.47 mM), a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cho...
T5181	CA-5f	1370032-19-1	99.83%
T5181	CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.
T4085	Paris saponin VII	68124-04-9	99.83%
T4085	Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
T5211	NSC 185058	39122-38-8	99.83%
T5211	NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.
T5173	SBI-0640756	1821280-29-8	99.83%
T5173	SBI-0640756 (SBI-756) (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.
T0711L	Niclosamide olamine	1420-04-8	99.83%
T0711L	Niclosamide olamine (Niclosamide Ethanolamine salt) is an Repellent, Insect Attractant and Chemosterilant.
T2393	Efavirenz	154598-52-4	99.83%
T2393	Efavirenz (DMP 266) is a Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of efavirenz is as a Non-N...
T1862	PR-619	2645-32-1	99.83%
T1862	PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs).
T1524	Nilotinib	641571-10-0	99.83%
T1524	Nilotinib (AMN107) is a second-generation Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
T3207	Briciclib	865783-99-9	99.82%
T3207	Briciclib (ON 014185) is a small molecule that suppresses cyclin D1 accumulation in Y cells.
TN3609	Catalposide	6736-85-2	99.82%
TN3609	Catalposide is a potent inducer of (HO)-1 isolated from Catalpa ovate G. Don (Bignoniaceae). Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, a...
T2111	Sepantronium bromide	781661-94-7	99.82%
T2111	Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity.