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Search Results for " ubiquitylation "

7

Compounds

Cat No. Product Name Synonyms Targets
T8561 Apcin APC
Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substr...
T39710 ARV-471 Vepdegestrant Estrogen Receptor/ERR
ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.
T3110 PRT4165 NSC600157,PRT 4165 BMI-1 , Others , E1/E2/E3 Enzyme
PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor.
T25465 GS143 GS-143,GS 143 IκB/IKK , E1/E2/E3 Enzyme , NF-κB
GS143 is a selec­tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup­presses NF-κB acti­va­tion and tran­scrip­tion of tar­get genes and does not inhibit protea...
T61512 FT3967385
FT3967385 is a newly developed compound that functions as a USP30 inhibitor, emulating the genetic deficiency of USP30. This inhibition serves as a catalyst for the amplification of mitochondrial ubiquitylation through t...
T69642 FT385
FT385 is a novel USP30 inhibitor, recapitulating genetic loss of USP30 and setting the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation.
T75133 NRX-0492
NRX-0492 is an orally administered compound that efficiently degrades Bruton's tyrosine kinase (BTK) by catalyzing its ubiquitylation and subsequent proteasomal degradation, achieving half-maximal degradation concentrati...
TargetMol