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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8561 | Apcin | APC | |
Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substr... | |||
T39710 | ARV-471 | Vepdegestrant | Estrogen Receptor/ERR |
ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer. | |||
T3110 | PRT4165 | NSC600157,PRT 4165 | BMI-1 , Others , E1/E2/E3 Enzyme |
PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor. | |||
T25465 | GS143 | GS-143,GS 143 | IκB/IKK , E1/E2/E3 Enzyme , NF-κB |
GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit protea... | |||
T61512 | FT3967385 | ||
FT3967385 is a newly developed compound that functions as a USP30 inhibitor, emulating the genetic deficiency of USP30. This inhibition serves as a catalyst for the amplification of mitochondrial ubiquitylation through t... | |||
T69642 | FT385 | ||
FT385 is a novel USP30 inhibitor, recapitulating genetic loss of USP30 and setting the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation. | |||
T75133 | NRX-0492 | ||
NRX-0492 is an orally administered compound that efficiently degrades Bruton's tyrosine kinase (BTK) by catalyzing its ubiquitylation and subsequent proteasomal degradation, achieving half-maximal degradation concentrati... |