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PRT4165

Catalog No. T3110 CAS 31083-55-3

Synonyms: NSC600157, PRT 4165

PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

PRT4165, CAS 31083-55-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 38.00
10 mg	In stock	$ 47.00
25 mg	In stock	$ 85.00
50 mg	In stock	$ 121.00
100 mg	In stock	$ 202.00
200 mg	In stock	$ 282.00
500 mg	In stock	$ 475.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.6%

Purity: 98.71%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor.
Targets&IC50	RING1A-BMI1:3.9 μM
In vitro	Inhibit the?in vitro?E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex and H2A/H2AX ubiquitination
In vivo	Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination?in vitro?and?in vivo.

Synonyms	NSC600157, PRT 4165
Molecular Weight	235.24
Formula	C15H9NO2
CAS No.	31083-55-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 23.5 mg/mL(100 mM)

References and Literature

1. Ismail, et al. J Biol Chem. 2013 Sep 13;288(37):26944-54. 2. Alchanati, et al. PLoS One. 2009 Dec 1;4(12):e8104.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library DNA Damage & Repair Compound Library HIF-1 Signaling Pathway Compound Library Bioactive Compounds Library Max Ubiquitination Compound Library Anti-Aging Compound Library Target-Focused Phenotypic Screening Library Bioactive Compound Library Anti-Metabolism Disease Compound Library Cell Cycle Compound Library

Related Products

Related compounds with same targets

PTC-209 PTC-028 XMD8-92 PTC-209 hydrobromide Unesbulin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PRT4165 31083-55-3 Cell Cycle/Checkpoint DNA Damage/DNA Repair Others Ubiquitination BMI-1 E1/E2/E3 Enzyme E1 activating enzyme NSC-600157 NSC600157 PRT-4165 E3 ligating enzyme Ubiquitin ligase E2 conjugating enzyme PRT 4165 NSC 600157 inhibit Inhibitor Ubiquitin conjugating enzyme Ubiquitin activating enzyme inhibitor

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