plaques — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9153	Picotamide		Others
	Picotamide has anticoagulant and fibrinolytic properties.		Others
T31091	CRANAD-28	CRANAD28	Others
	CRANAD-28 is a blood-brain barrier (BBB) penetrating two-photon imaging probe capable of visualizing amyloid plaques and labeling plaques and cerebral amyloid angiopathy.		Others
T1068	Dithranol	1,8,9-trihydroxyanthracene,cignoline,Anthralin	Others , DNA/RNA Synthesis
	Dithranol (cignoline) is an anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially PSORIASIS. It may cause FOLLICULITIS.		Others , DNA/RNA Synthesis
T23131	PE 154		AChE
	PE 154 is a potent fluorescent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 280 pM and 16 nM respectively. PE 154 is commonly used to label β-amyloid plaques in histochemical an...		AChE
T30506	BMS-212122	UNII-0Z473OO6GB,BMS212122,BMS 212122	CETP
	BMS-212122 (UNII-0Z473OO6GB) is a potent inhibitor of microsomal triglyceride transfer protein (MTP) and has shown hypolipidemic effects in animal studies.BMS-212122 significantly reduced lipid content and monocyte-deriv...		CETP
T17157	TRAF-STOP inhibitor 6877002	CD40-TRAF6 inhibitor	NF-κB
	TRAF-STOP inhibitor 6877002 (CD40-TRAF6 inhibitor), is a selective inhibitor of CD40-TRAF6 interaction. TRAF-STOP 6877002 reduces leukocyte recruitment, and reduces macrophage activation; reduces macrophage proliferation...		NF-κB
T31801	Florbetapir F-18
	Florbetapir F-18 is a PET agent for Abeta plaques.
T10529	BF-168		Others
	BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).		Others
T33448	ML 10	ML-10,ML10
	ML 10 is is a [18F] positron emission tomography (PET) radiotracer that accumulates in cells presenting apoptosis-specific membrane alterations. [18F]ML-10 allows for the detection of apoptotic cells located in atheroscl...
T74786	BIBD-124
	BIBD-124, with an IC50 value of 9.51 nM, effectively binds to amyloid beta (Aβ) plaques. The fluorinated variant, [18F]BIBD-124, serves as a radiotracer for imaging Aβ plaques [1].
TP1729	β-Amyloid (10-35), amide
	β-Amyloid (10-35), amide, is a chemical compound consisting of 26 amino acids, specifically residues 10-35 of the Aβ peptide. It serves as the primary constituent of amyloid plaques found in Alzheimer's disease.
T36727	9(S)-HODE
	9(S)-HODE is produced by the lipoxygenation of linoleic acid in both plants and animals.[1],[2] It has been detected in atherosclerotic plaques, as an esterified component of membrane phospholipids and in oxidized LDL pa...
T38149	β-Amyloid (1-43)(human)
	The amyloid β-protein is a 39- to 43-amino acid polypeptide that is the primary constituent of senile plaques and cerebrovascular deposits in Alzheimer's disease and Down's syndrome. Additionally it acts as an inhibitor ...
T39302	β-Amyloid (1-38), mouse, rat
	β-Amyloid (1-38), derived from mice and rats, is a chemical compound comprising 38 amino acids, specifically residues 1-38 of the Aβ peptide. Notably, it serves as the primary constituent of amyloid plaques associated wi...
T75751	β-Amyloid (1-40) (TFA)
	β-Amyloid (1-40) TFA, a principal protein in plaques observed in the brains of Alzheimer's disease patients [1], is pivotal in research focused on this neurodegenerative disorder.
T36948	NIAD-4
	NIAD-4 is a fluorescent probe that crosses the blood-brain barrier to bind with high affinity to amyloid-β (Aβ) plaques (Ki = 10 nM). It displays excitation/emission spectra of 475/625 nm, respectively, with the far-red ...
TP1228	β-Amyloid (1-16)	Amyloid β-Protein (1-16),β-Amyloid 1-16
	β-Amyloid (1-16) is an amyloidogenic protein fragment with a sequence derived from β-amyloid. It exhibits the ability to bind to metal ions, indicating its involvement in metal-binding processes. β-Amyloid, a peptide, is...
T74143	AZD4694 Precursor
	AZD4694 Precursor (AZ13040214) serves as the foundational compound for synthesizing [18F]AZD4694, a high-affinity amyloid-β imaging ligand targeting amyloid-β plaques [1].
T75378	DCDAPH
	DCDAPH (Compound 2c), a novel smart near-infrared fluorescence (NIRF) probe, efficiently detects β-amyloid (Aβ) plaques with an excitation/emission wavelength (λ ex /λ em) of 597/665 nm in PBS. It demonstrates high affin...
TP1673	β-Amyloid (11-22)	β-Amyloid 11-22
	β-Amyloid (11-22) is a peptide fragment of β-Amyloid.Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be the cause of Alzheimer’s Disease (AD). A...