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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11282 | FGTI-2734 | Transferase | |
FGTI-2734 is a dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor, exhibiting IC50 values of 250 nM and 520 nM for FT and GGT-1, respectively. It effectively prevents the membrane localizat... | |||
T9167 | PF-9363 | CTX-3648 | Histone Acetyltransferase |
PF-9363 (CTX-3648) is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer. | |||
T2069L | TH287 hydrochloride | DNA/RNA Synthesis , MTH1 | |
TH287 is a selective MTH1 inhibitor(IC50 : 0.8 nM). It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts. | |||
T60372 | ALDH3A1-IN-1 | ||
ALDH3A1-IN-1 (Compound 18) is a potent ALDH3A1 inhibitor with an IC 50 of 1.61 μM. ALDH3A1-IN-1 is more potent than DEAB against patient-derived primary prostate tumor epithelial cells, as single agents or in combination... | |||
T35822 | CAY10722 | ||
CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functio... | |||
T83716 | KSL-128114 TFA | Ac-rRrGrKkRrSHWX1X2DI-OH (X1=tert-Leucine; X2=Cyclohexylglycine) | |
KSL-128114, a peptide inhibitor of the membrane regulator syntenin (Ki = 300 nM), notably diminishes the viability of A2058 melanoma and patient-derived glioblastoma multiforme (GBM) cells in a concentration-dependent ma... | |||
T11282L | FGTI-2734 mesylate (1247018-19-4 free base) | FGTI-2734 mesylate | Others |
FGTI-2734 mesylate, a RAS C-terminal mimetic compound with dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitory activities (IC50s of 250 nM and 520 nM for FT and GGT, respectively), mitigates ... | |||
T66481 | TG-693 | ||
TG693, an orally available inhibitor of CLK1, promotes the skipping of the endogenous mutated exon 31 in Duchenne muscular dystrophy (DMD) patient-derived cells and increased the production of the functional exon 31-skip... | |||
T35670 | Miro1 Reducer | ||
Promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochon... | |||
T83281 | 6-(1-Hydroxyethyl)-5,6-dihydrochelerythrine | ||
6-(1-Hydroxyethyl)-5,6-dihydrochelerythrine, an alkaloid, markedly alters the characteristics of cellular organelles—specifically, early endosomes, mitochondria, and autophagosomes—in Parkinson’s Disease patient-derived ... | |||
T70134 | L-778123 Dihydrochloride | ||
L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity... | |||
T79461 | YK-029A | EGFR | |
YK-029A, an orally active EGFR mutant inhibitor, targets both EGFR T790M and EGFRex20ins mutations. It demonstrates notable antitumor efficacy, inducing tumor regression in EGFRex20ins-driven patient-derived xenograft (P... | |||
T73429 | VT02956 | ||
VT02956 is a LATS inhibitor ( IC 50 : 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organo... | |||
T36275 | XStAx-VHLL | ||
Selective peptide-based β-catenin Degrader. Comprises a β-catenin-targeted stapled peptide, xStAx, linked to a VHL-binding peptide. Reduces β-catenin levels in HEK293T cells and colorectal cancer cell lines. Selectively ... | |||
T35481 | DD 03-171 | ||
Potent and selective BTK Degrader (IC50 = 5.1 nM); degrades BTK in a proteasome- and CRBN-dependent manner. Suppresses BTK signaling and proliferation in mantle cell lymphoma (MCL) cells by degrading BTK, IKFZ1, and IKFZ... | |||
T62676 | DS89002333 | ||
DS89002333 is a potent, orally active PRKACA inhibitor (IC50: 0.3 nM).DS89002333 has shown good antitumor effects in a patient-derived xenograft model of FL-HCC expressing a DNAJB1-PRKACA fusion gene.DS89002333 can be us... | |||
T78877 | MTX-241F | EGFR | |
MTX-241F, a selective small molecule inhibitor, targets members of the EGFR and PI3 kinase families. It penetrates the blood-brain barrier, providing long-term tumor growth control and exhibits radiosensitizing activity ... | |||
T36451 | 1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt) | 1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt),biotin-cap-DPPE | |
1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid. It has been used in PEGylated polyamidoamine-dendrimer-conjugated supported lipid bilayers (SLB) to isolate circulating tumor cells and tumor... | |||
T76791 | Seribantumab | ||
Seribantumab (MM 121), a fully human IgG2 monoclonal antibody, specifically targets HER3, inhibiting the activation of the epidermal growth factor receptor (ErbB) family and its subsequent signaling. This action effectiv... | |||
T77012 | Flotetuzumab | ||
Flotetuzumab (MGD006; S80880), an investigational CD123/CD3 bispecific dual-affinity retargeting antibody (DART) molecule, reactivates T cells through concurrent engagement with CD123 on target cells and CD3 on effector ... |