mglur2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T38910	mGluR2 antagonist 1
	mGluR2 antagonist 1 is a potent and selective class of negative allosteric modulator targeting the metabotropic glutamate receptor 2 (mGluR2) with high oral bioavailability. It displays a remarkable affinity for mGluR2, ...
T62202	mGluR2 modulator 1
	mGluR2 modulator 1 (compound 95) is a potent, blood-brain-barrier permeable modulator of mGluR2 (metabotropic glutamate receptor-2) positive transmutation (EC50: 0.03 μM). mGluR2 modulator 1 can be used in the study of p...
T60882	mGluR2 modulator 2
	mGluR2 modulator 2 (compound 2) can be used in antipsychotic research. mGluR2 modulator 2 is a potent, selective and orally bioavailable positive allosteric modulator of mGluR2 with an EC 50 value of 0.13 μM [1].
T61277	mGluR2 modulator 4
	mGluR2 modulator 4 (compound 47) is a highly potent positive allosteric modulator of mGluR2, exhibiting an EC 50 value of 0.8 μM. It holds the potential for investigating antipsychotic properties [1].
T15090	Decoglurant	RO4995819	GluR
	Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3 and it also is developed as an antidepressant.		GluR
T10432L	AZD-8529 mesylate		GluR
	AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 ...		GluR
T3479	(RS)-MCPG	alpha-MCPG,(±)-MCPG	GluR
	(RS)-MCPG ((±)-MCPG) is a non-selective group I/II metabotropic glutamate receptor antagonist.		GluR
T27932	LY-2300559	LY2300559	GluR
	LY-2300559 is an agonist of metabotropic glutamate receptor 2 (mGluR2) and can be used in studies about the treatment of migraine.		GluR
T15812	LY2979165	mGlu2 agonist	GluR
	LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.		GluR
T3464	PHCCC	(-) PHCCC	GluR
	PHCCC ((-) PHCCC) is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mGluR2 and mGluR8.		GluR
T3484	Trans-ACPD	Trans-(±)-ACP,1-amino-1,3-dicarboxycyclopentane,(±)-trans-ACPD	GluR
	trans-ACPD ((±)-trans-ACPD) is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD. trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate receptor); active at the group I/II mGlu receptors (EC50: 2/1...		GluR
T41301	L-Cysteinesulfinic acid monohydrate		GluR
	L-Cysteinesulfinic acid monohydrate is a potent agonist at rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectiv...		GluR
T6022	LY404039	pomaglumetad	Glucocorticoid Receptor , GluR
	LY404039 (pomaglumetad) is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).		Glucocorticoid Receptor , GluR
T27942	LY307452	LY 307452,LY-307452
	LY307452 is a selective antagonist of mGluR2/3.
T10432	AZD-8529		Others
	AZD-8529 is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.		Others
T9353	OXOMEMAZINE		AChR , Histamine Receptor
	Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic activity. Oxomemazine is a selective antagonist of mycotoxins M1 receptors, showing high (Ki=84 nM, M1 receptors) and low ...		AChR , Histamine Receptor
T14615	Biphenylindanone A	BINA	GluR
	Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.		GluR
T23294	(S)-4C3HPG		Others
	group I mGlu1a/1a receptor antagonist and mGluR2 agonist		Others
T27449	GSK1331268	GSK 1331268,GSK-1331268
	GSK1331268 is a selective, orally bioavailable positive modulators of mGluR2.
T27448	GSK1331258	GSK 1331258,GSK-1331258
	GSK1331258 is a selective, orally bioavailable positive modulators of mGluR2.