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Search Results for " hydroxysteroid "

20

Compounds

Cat No. Product Name Synonyms Targets
T76147 3α-Hydroxysteroid dehydrogenase
3α-Hydroxysteroid dehydrogenase (3α-HSD), encoded by the AKR1C4 gene, is responsible for catalyzing the transformation of 3-ketosteroids into 3α-hydroxy compounds. This enzyme significantly contributes to the inactivatio...
T2207 Adrenosterone 11-ketoandrostenedione,11-oxoandrostenedione,Reichstein's substance G Androgen Receptor , Endogenous Metabolite
Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.
T68664 Epostane Win-32729 Dehydrogenase
Epostane (Win-32729) is a 3β-hydroxysteroid dehydrogenase inhibitor that acts by inhibiting the enzyme 3β-hydroxysteroid dehydrogenase, blocking progesterone production.
T14151 AKR1C1-IN-1 NADPH
AKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase (AKR1C1) inhibitor (Ki: 4 nM for AKR1C1).
T14388 AZD 4017 Dehydrogenase
AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).
T71394 BMS-823778
BMS-823778 is an orally available potent and selective inhibitor of 11-β-hydroxysteroid-dehydrogenase 1 (11βHSD-1). BMS-823778 is a potential therapeutic agent for type 2 diabetes mellitus (T2DM).
T9594 BI-187004 Dehydrogenase
BI-187004 is an 11β-hydroxysteroid dehydrogenase 1 inhibitor.
T67903 11β-HSD1 inibitor 17 Dehydrogenase
11β-HSD1 inibitor 17 is an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD1).
T13100 TC HSD 21 Dehydrogenase
TC HSD 21 is a potent and highly selective inhibitor of 17β-hydroxysteroid dehydrogenase type 3 (IC50 = 14 nM).
T0238 2-(Acetyloxy)-3-Methylbenzoic Acid Others
2-(Acetyloxy)-3-Methylbenzoic Acid is used in qHTS Assay for Inhibitors of hydroxysteroid (17-beta) dehydrogenase 4, HSD17B4 with activity value of 19.95 μM
T3542 BVT-14225 BVT 14225 Dehydrogenase
BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor (IC50=52 nM).
T1473 Trilostane Win 24540 Dehydrogenase
Trilostane (Win 24540) is a synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex.
T77576 17β-HSD10-IN-1 Dehydrogenase , Endogenous Metabolite
17β-HSD10-IN-1 is an orally available 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) inhibitor with blood-brain permeability and potency for the study of Alzheimer's disease.
T77606 WAY-311610 Dehydrogenase
WAY-311610 is an 11β-hydroxysteroid dehydrogenase HSD11B1 inhibitor that inhibits the 11β-HSD1 enzyme with an IC = 0.34 μM.It can be used to study neuropathic pain, inflammatory pain, and occipital neuralgia.
T73446 BI‑3231 Dehydrogenase
BI‑3231 is a selective and potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 HSD17B13, inhibiting hHSD17B13 and mHSD17B13.BI-3231 can be used for the study of alcohol-associated liver injury, fibrosis and cirrhosis...
T16510 PF-915275 Dehydrogenase
The dose-dependent effect of PF-915275 on the conversion of cortisone to cortisol in primary human and monkey hepatocytes (EC50: 20 and 100 nM, respectively). PF-915275 is an effective and selective human 11β-hydroxyster...
TJS0341 7-Amino-4-(trifluoromethyl)coumarin Coumarin 151,AFC 5-HT Receptor
7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a 5-Hydroxytryptamine Receptor Subtype 1E (HTR1E) antagonist. 7-Amino-4-(trifluoromethyl)coumarin is a Galanin Receptor 2 (GALR2) antagonist. 7-Amino-4-(trifluorometh...
T22458 WEHL-04 7-Bromo-1,2,3,4-tetrahydroquinoline Others
WEHL-04 is an intermediate used to prepare (isoquinolinylsulfonyl)benzoic acids as inhibitors of type 5 71-β-hydroxysteroid dehydrogenase AKR1C3. It is also used in the synthesis of 2-aminooctahydrocyclopentalene-3a-carb...
T0522 Diammonium Glycyrrhizinate Glycyrrhizin Dehydrogenase
Diammonium Glycyrrhizinate (Glycyrrhizin) , an extensively used anti-inflammatory agent, is isolated from the licorice root. It is metabolized to glycyrrhetinic acid, which inhibits 11-β-hydroxysteroid dehydrogenase and ...
T14001 11-Beta-hydroxyandrostenedione NSC-17102,4-Androsten-11β-ol-3,17-dione Endogenous Metabolite
11-Beta-hydroxyandrostenedione (NSC-17102) is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozyme...
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