gyrase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T78866	DNA Gyrase-IN-9		DNA/RNA Synthesis
	DNA Gyrase-IN-9 (compound 4j), an antibacterial agent, selectively targets DNA gyrase. It exhibits a minimum inhibitory concentration (MIC) of 0.5-2 µg/mL for Gram-positive bacteria inhibition and a minimum bactericidal ...		DNA/RNA Synthesis
T62895	DNA Gyrase-IN-4
	DNA Gyrase-IN-4 (compound 8p) is a potent inhibitor of DNA cyclooxygenase (IC50: 0.13 μM). (MIC: 0.05 μg/ml), Salmonella (MIC: 0.05 μg/ml) and Escherichia coli (MIC: 8 μg/ml).
T63442	DNA Gyrase-IN-2
	DNA Gyrase-IN-2 is a bacterial DNA cyclooxygenase B inhibitor that acts on Escherichia coli DNA cyclooxygenase (IC50: 3.29-10.49 μM) and Mycobacterium tuberculosis DNA cyclooxygenase (IC50: 4.41-5.61 μM), exhibiting anti...
T61937	DNA Gyrase-IN-3
	DNA Gyrase-IN-3 (Compound 28) is an inhibitor of bacterial DNA gyrase B. The IC50 of DNA Gyrase-IN-3 inhibits Escherichia coli DNA rotatase is 5.41-15.64 μM. DNA Gyrase-IN-3 shows anti-tuberculosis and antibacterial acti...
T63395	DNA Gyrase-IN-5
	DNA Gyrase-IN-5 is a potent inhibitor of DNA gyrase (IC50: 0.10 μM) and has an antibacterial effect on both wild-type and drug-resistant strains.
T78712	DNA Gyrase-IN-8		DNA/RNA Synthesis
	DNA Gyrase-IN-8 is a potent inhibitor of DNA gyrase, demonstrating antimicrobial activity with an IC50 of 8.45 µM [1].		DNA/RNA Synthesis
T63681	DNA Gyrase-IN-1
	DNA Gyrase-IN-1 is a potent and selective DNA promoter inhibitor (IC50: 2.6 μM). DNA Gyrase-IN-1 inhibits Mycobacterium tuberculosis (Mtb) activity well (MIC: 0.49 μM). DNA Gyrase-IN-1 can be used to study tuberculosis.
T74848	DNA Gyrase-IN-6
	Antibacterial agent 138, a benzothiazole inhibitor, targets bacterial DNA gyrase and topoisomerase IV, exhibiting both favorable solubility and plasma protein binding. It demonstrates antibacterial activity against Gram-...
T79240	DNA gyrase B-IN-2
	DNA gyrase B-IN-2 (Compound E), a 2-aminobenzothiazole derivative, serves as a potent inhibitor of DNA gyrase B with substantial efficacy against ESKAPE pathogens. The compound exhibits potent nanomolar-range inhibition ...
T64012	DNA gyrase B-IN-1
	DNA gyrase B-IN-1 is a potent inhibitor of DNA gyrase B, exhibiting good binding affinity and stability. DNA gyrase B-IN-1 inhibits P. aeruginosa/i> DNA gyrase B (IC50: 2.2 μM).
T78776	DNA gyrase B-IN-3		DNA/RNA Synthesis
	DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against Gram-positive strains [1].		DNA/RNA Synthesis
T62792	14α-Demethylase/DNA Gyrase-IN-1
	14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.
T62389	14α-Demethylase/DNA Gyrase-IN-2
	14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.
T8747	Levofloxacin hydrochloride		DNA gyrase , Topoisomerase
	Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inh...		DNA gyrase , Topoisomerase
T13231L	Trovafloxacin mesylate		Others , DNA/RNA Synthesis , Topoisomerase , Antibacterial
	Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. It also acts as an effective and specific inhibitor of the ...		Others , DNA/RNA Synthesis , Topoisomerase , Antibacterial
T0909	Nalidixic acid	NSC-82174	Topoisomerase , Antibacterial , Antibiotic
	Nalidixic acid (NSC-82174) is a synthetic 1, 8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.		Topoisomerase , Antibacterial , Antibiotic
T6567	Levofloxacin	Levaquin,Cravit,Tavanic,Fluoroquinolone,(-)-Ofloxacin	Topoisomerase , Antibacterial , Antibiotic
	Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.		Topoisomerase , Antibacterial , Antibiotic
T7865	Danofloxacin	Danofloxacino,Danofloxacin free base,Danofloxacine	Others , DNA/RNA Synthesis , Antibacterial , Antibiotic
	Danofloxacin (Danofloxacin free base) is a fluoroquinolone antibiotic used in veterinary medicine.		Others , DNA/RNA Synthesis , Antibacterial , Antibiotic
T0909L	Nalidixic acid sodium salt	Baktogram,Sodium nalidixate	Topoisomerase , Antibacterial , Antibiotic
	Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.		Topoisomerase , Antibacterial , Antibiotic
T7804	Garenoxacin mesylate hydrate	Garenoxacin mesylate [USAN],BMS284756 (Mesylate hydrate)	Antibacterial
	Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strains.		Antibacterial