fibrils — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22118	NQTrp		Microtubule Associated
	NQTrp is an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects.		Microtubule Associated
T2987	(-)-Epigallocatechin	l-Epigallocatechin,Epigallocatechin,EGC	MMP , Autophagy
	(-)-Epigallocatechin, the predominant flavonoid in green tea, possesses the unique ability to attach to unfolded native polypeptides, thereby inhibiting their transformation into amyloid fibrils.		MMP , Autophagy
T13048	SynuClean-D	SC-D	Others
	SynuClean-D (SC-D) is an α-synuclein aggregation inhibitor preventing fibril propagation, disrupting mature amyloid fibrils, and abolishing the degeneration of dopaminergic neurons in an animal model of Parkinson’s disea...		Others
T35941	DC-Chol hydrochloride	Cholesteryl 3β-N-(dimethylaminoethyl)carbamate hydrochloride,DC-Chol (hydrochloride),DC-Cholesterol hydrochloride,Cholesteryl 3β-N-(dimethylaminoethyl)carbamate	Beta Amyloid
	DC-Chol hydrochloride(DC-Cholesterol hydrochloride) inhibited the formation of Aβ40 fibrils under appropriate experimental conditions and significantly inhibited amyloid formation from oxidized hCT in a dose-dependent ma...		Beta Amyloid
T19837	O4	O 4,O-4
	O4 is a novel stabilizer of amyloid- fibrils. O4 used for accelerating the formation of end-stage mature fibrils.
T68836	ADS-J1
	ADS-J1 is an HIV-1 entry inhibitor that potently inhibits seminal amyloid fibrillization and block fibril-mediated enhancement of viral infection. Semen-derived amyloid fibrils, comprising SEVI (semen-derived enhancer of...
T32609	Lawsoniaside
	Lawsoniaside can hinder the growth of amyloid-β42 fibrils.
T10530	BF 227		Others
	BF 227 is a candidate for an amyloid imaging probe for PET (Ki: 4.3 nM for Aβ1-42 fibrils).		Others
T19730	12-Crown-4	12 C 4,12-Crown-4 ether,12C4,12-C-4
	12-Crown-4 disrupts Aβ40 fibrils. 12-Crown-4 can enter into the hydrophobic core region and form competitive, hydrophobic interactions with key hydrophobic residues.
T19018	K114		Others
	K114 binds tightly to amyloid fibrils (EC50: 20-30 nM). K114 is an efficient detector of semen-derived enhancer of virus infection (SEVI).		Others
T83106	Anselamimab
	Anselamimab (CAEL-101), a humanized IgG1-κ anti-amyloid fibrils antibody, specifically targets serum amyloid A1 (SAA1) [1] [2].
T74158	Aβ Fibrillization modulator 1
	Aβ Fibrillization Modulator 1 stabilizes amyloid-beta (Aβ) monomers, preventing their aggregation into fibrils.
T37370	Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)
	Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide. It forms fibrils that react to thioflavin T and Congo red an...
TP1645	β-Amyloid (1-9)	β-Amyloid 1-9
	This is an N-terminal fragment of beta amyloid. It consists of amino acid residues 1 to 9. Truncated beta amyloid peptide (10-40) still forms amyloid fibrils and shows fibril polymorphism.
T40641	Crocin-4
	Crocin-4, a carotenoid compound found in saffron, possesses potent antioxidant properties and can penetrate the brain. It effectively inhibits the aggregation and deposition of Aβ fibrils, making it useful for Alzheimer'...
T39638	Eprodisate
	Eprodisate is a novel compound specifically developed to disrupt the interactions between amyloidogenic proteins and glycosaminoglycans, effectively impeding the polymerization of amyloid fibrils and their deposition in ...
T35627	Amylin (human) (trifluoroacetate salt)
	Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety. It binds to amylin receptors with IC50 values...
T60335	BTA-1
	BTA-1 is an uncharged derivative of thioflavin-T that has high affinity for Aβ fibrils and shows very good brain entry and clearance [1].
T73495	Q-FTAA
	q-FTAA, a potential research compound for Alzheimer's disease (AD), demonstrates binding affinity to Aβ1-42 fibrils and the Alzheimer's disease PIB binding complex (ADPBC), with EC50 values ranging from 330-630 nM and 30...
T37472	TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)
	TAMRA-Amyloid-β (1-42) peptide is a fluorescently labeled peptide. Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-residue protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's...