Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BF 227 is a candidate for an amyloid imaging probe for PET (Ki: 4.3 nM for Aβ1-42 fibrils).
Description | BF 227 is a candidate for an amyloid imaging probe for PET (Ki: 4.3 nM for Aβ1-42 fibrils). |
Targets&IC50 | β-Amyloid (1–42):ki: 4.3 nM |
In vitro | BF-227 has a high binding affinity for Aβ1-42 fibrils. The Ki value for Aβ1-42 fibrils in competitive binding assay using [125I]BF-180 is 4.3 nM in BF-227 (Kd value of [125I]BF-180: 10.8 nM)[1]. The AUC for BF-227 (0.994) is much higher than that for FDG (0.839), indicating that BF-227 is more sensitive as well as more specific than FDG in diagnosing AD [2]. |
Molecular Weight | 333.38 |
Formula | C16H16FN3O2S |
CAS No. | 845647-80-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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BF 227 845647-80-5 Others BF-227 BF227 inhibitor inhibit