Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SynuClean-D (SC-D) is an α-synuclein aggregation inhibitor preventing fibril propagation, disrupting mature amyloid fibrils, and abolishing the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 177.00 | |
5 mg | In stock | $ 374.00 | |
10 mg | In stock | $ 597.00 | |
25 mg | In stock | $ 964.00 | |
50 mg | In stock | $ 1,290.00 | |
100 mg | In stock | $ 1,760.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 411.00 |
Description | SynuClean-D (SC-D) is an α-synuclein aggregation inhibitor preventing fibril propagation, disrupting mature amyloid fibrils, and abolishing the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease. |
In vitro | SynuClean-D prevents fibril propagation in protein-misfolding cyclic amplification assays and decreases the number of α-synuclein inclusions in human neuroglioma cells. SynuClean-D significantly reduces the aggregation of wild-type α-synuclein and the familiar A30P and H50Q variants in a substoichiometric molar ratio. SynuClean-D can bind to cavities in mature α-synuclein fibrils[1]. |
In vivo | SynuClean-D-treated worms show decreased α-synuclein aggregation in muscle and a concomitant motility recovery. SynuClean-D is able to rescue dopaminergic neurons from α-synuclein-induced degeneration[1]. In two parkinson’s disease (PD) Caenorhabditis elegans models, SynuClean-D expresses α-synuclein either in muscle or in dopaminergic neurons and significantly reduces the toxicity exerted by α-synuclein[1]. |
Synonyms | SC-D |
Molecular Weight | 354.2 |
Formula | C13H5F3N4O5 |
CAS No. | 685121-45-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 77 mg/mL (217.39 mM)
You can also refer to dose conversion for different animals. More
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SynuClean-D 685121-45-3 Others inhibit Inhibitor SynuClean D SC-D SynuCleanD inhibitor