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Search Results for " end-joining "

11

Compounds

Cat No. Product Name Synonyms Targets
T10981 DCZ0415 Apoptosis , Others , NF-κB
DCZ0415 induces antimyeloma activity in vitro, in vivo and in primary cells of drug-resistant myeloma patients. DCZ0415 is a potent TRIP13 inhibitor that can impair the repair of non-homologous end junctions and inhibit ...
T1724 SCR7 pyrazine SCR7 Apoptosis , DNA/RNA Synthesis , CRISPR/Cas9
SCR7 pyrazine (SCR7) enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold. Inhibits nonhomologous end-joining (NHEJ).
T3340 SCR7 Apoptosis , DNA/RNA Synthesis , CRISPR/Cas9
SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).
T40236 ART812 ART812 DNA/RNA Synthesis
ART812 is an orally active inhibitor of DNA polymerase Polθ, possessing an IC50 value of 7.6 nM. Additionally, ART812 exhibits a cell-based microhomology-mediated end joining (MMEJ) IC50 value of 240 nM.
T8880 PFM01 Others
PFM01 is an inhibitor of MRE11 endonuclease. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR).
T23974 DDRI-18 DDRI18,DDRI 18 DNA/RNA Synthesis
DDRI-18 is a novel small molecule inhibitor that regulates the DNA damage response with sensitizing and anticancer activities, inhibits non-homologous end-joining (NHEJ) DNA repair and enhances the cytotoxicity of antica...
T8637 DMNB 6-Nitroveratraldehyde DNA-PK
DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human c...
T4339 YU238259 DNA-PK , Others
YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.
T6960L PU-H71 HCl PU-H71 HCl(873436-91-0 Free base),Zelavespib HCl HSP , DNA/RNA Synthesis
PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT. PU-H71 HCL shows antitumor activity in many preclinical models of maligna...
T60621 PFM03
PFM03 is an inhibitor of MRE11 Endonuclease that regulates DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) [1].
T74501 NHEJ inhibitor-1
NHEJ Inhibitor-1 (Compound C2), a trifunctional Pt(II) complex, mitigates non-homologous end joining (NHEJ)/homologous recombination (HR)-related double strand break (DSB) repairs, combating Cisplatin resistance in non-s...
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