cyclase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11424	Glutaminyl Cyclase Inhibitor 1		Guanylate cyclase
	Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor (IC50: 0.5 μM) that can be used to study neurological disorders.		Guanylate cyclase
T38770	Guanylate cyclase-IN-1
	Guanylate cyclase-IN-1 (Example 46) is a specific inhibitor of guanylate cyclase, employed in research related to cardiovascular diseases.
T16333	NKY80	Adenylyl cyclase type V Inhibitor	Adenylyl cyclase
	NKY80 regulates the adenylyl cyclase catalytic activity in heart and lung tissues. NKY80 is a non-competitive inhibitor of adenylyl cyclase type V isoform (IC50s: 8.3 µM, 132 µM, and 1.7 mM for type V, III and II, respe...		Adenylyl cyclase
T11423	Glutaminyl Cyclase Inhibitor 4		Others
	Glutaminyl Cyclase Inhibitor 4 is a potent, selective glutaminyl cyclase (QC) inhibitor (IC50: 6.1 nM). It is a potent anti-Alzheimer’s agent.		Others
T11425	Glutaminyl Cyclase Inhibitor 2		Others
	Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor (IC50: 1.23 μM).		Others
T11422	Glutaminyl Cyclase Inhibitor 3		Others
	Glutaminyl Cyclase Inhibitor 3, a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor (IC50: 4.5 nM). It significantly reduced the brain concentrations of pyroform Aβ and total Aβ and ...		Others
T72136	Glutaminyl Cyclase Inhibitor 5
	Glutaminyl Cyclase Inhibitor 5 is a potent, selective inhibitor of human glutaminyl cyclase (hQC), demonstrating an inhibition concentration half-max (IC 50) of 3.2 nM.
T83169	Adenylyl cyclase-IN-1
	Adenylyl cyclase-IN-1 is a potential adenylyl cyclase inhibitor for ocular hypotonia research [1].
T63893	Adenylyl cyclase type 2 agonist-1
	Adenylyl cyclase type 2 agonist-1 is a potent agonist of adenylyl cyclase type 2 (AC2) (EC50: 90 nM). It is a potential lead compound in the fight against respiratory diseases.
T15658	KH7		cAMP , AChR
	KH7 is a soluble inhibitor of adenylyl cyclase (sAC)-specific. It has IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibito...		cAMP , AChR
T9080	Plecanatide		Guanylate cyclase
	Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist.		Guanylate cyclase
T10066	2',5'-Dideoxyadenosine		Adenylyl cyclase , Adrenergic Receptor , AChR
	2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM).		Adenylyl cyclase , Adrenergic Receptor , AChR
T16938	ST034307		Adenylyl cyclase
	ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).		Adenylyl cyclase
T16808	Runcaciguat		Others , Guanylate cyclase
	Runcaciguat is a soluble guanylate cyclase stimulator. Runcaciguat combines with selective partial adenosine A1 receptor agonists and can be used in studies about cardiovascular and renal diseases.		Others , Guanylate cyclase
T11852	Linaclotide		Guanylate cyclase
	Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guanylate cyclase C agonist.		Guanylate cyclase
T60003	AC1-IN-1		Adenylyl cyclase
	AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM).		Adenylyl cyclase
T0322	Fipexide		Dopamine Receptor , AChR
	Fipexide (Attentil, Vigilor), a psychoactive drug of the piperazine chemical class, was developed in Italy in 1983. It was served as a nootropic drug in France and Italy, mainly for the therapy of senile dementia, but is...		Dopamine Receptor , AChR
T21607	Ataciguat	HMR-1766	Others , Guanylate cyclase
	Ataciguat (HMR-1766) (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator.		Others , Guanylate cyclase
T80069	PACAP (6-27) (human, ovine, rat)	Pituitary adenylate cyclase-activating peptide (6-27)
	PACAP (6-27) (human, ovine, rat) serves as an antagonist for the PACAP receptor, inhibiting the catecholamine response of the canine adrenal gland to vasoactive intestinal peptide (VIP). This compound holds promise for r...
T16275	NB001	HTS 09836	Adenylyl cyclase
	NB001 (HTS 09836) is an inhibitor of adenyl cyclase 1 exhibiting effects on neural and non-neural pain.		Adenylyl cyclase