vhl — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T83649	VHL 15a

T13958	VHL Ligand 8		Others
	VHL Ligand 8, a VHL ligand essential for synthesizing ARD-266, acts as a highly potent VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. It efficiently facilitates the degradation of AR protein in AR-positive p...		Others
T7752	(S,R,S)-AHPC-Me	VHL ligand 2,E3 ligase Ligand 1A	Ligand for E3 Ligase
	(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771. ARV-771 is a...		Ligand for E3 Ligase
T35479	CRBN-6-5-5-VHL
	Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable. ...
T4207	(S,R,S)-AHPC hydrochloride	VHL Ligand 1 hydrochloride,ULM-1,Protein degrader 1 hydrochloride	Others , Ligand for E3 Ligase
	(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).		Others , Ligand for E3 Ligase
T8412	(S,R,S)-AHPC	VH032-NH2,MDK7526,VHL ligand 1	Others , Ligand for E3 Ligase
	(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor.		Others , Ligand for E3 Ligase
T17927	(S,R,S)-AHPC TFA	VH032-NH2 TFA,VHL ligand 1 TFA	Others , Ligand for E3 Ligase
	(S,R,S)-AHPC TFA (VHL ligand 1 TFA) (VH032-NH2 TFA) is a VH032-based ligand designed for von Hippel-Lindau (VHL) protein recruitment. This compound can be linked to protein ligands (e.g., BCR-ABL1) using a linker to crea...		Others , Ligand for E3 Ligase
T13671	(S,R,S)-AHPC-Me hydrochloride	VHL ligand 2 hydrochloride,E3 ligase Ligand 1	Others , Ligand for E3 Ligase
	(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cell...		Others , Ligand for E3 Ligase
T18873	VHL Ligand-Linker Conjugates 17		Others
	VHL Ligand-Linker Conjugates 17 are chemical compounds that consist of a VHL ligand specialized for the E3 ubiquitin ligase, as well as a PROTAC linker. These conjugates are utilized in the synthesis of various PROTACs, ...		Others
T17922	(S,R,S)-AHPC-PEG3-NH2 hydrochloride	VHL Ligand-Linker Conjugates 1 hydrochloride,E3 ligase Ligand-Linker Conjugates 5,VH032-PEG3-NH2 hydrochloride,VHL Ligand-Linker Conjugates 1 HCl	Others , E3 Ligase Ligand-Linker Conjugate
	(S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) is an E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC-based VHL ligand and 3-unit PEG linker.		Others , E3 Ligase Ligand-Linker Conjugate
T17877	VH032-cyclopropane-F	VHL ligand 3,E3 ligase Ligand 19,Phenolic VH101	Others , Ligand for E3 Ligase
	VH032-cyclopropane-F (Phenolic VH101) is a VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein by a linker to form PROTACs. PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4.		Others , Ligand for E3 Ligase
T82928	Azido-PEG2-VHL		PROTACs
	Azido-PEG2-VHL is a multikinase degrader utilized in PROTACs (PROteolysis TArgeting Chimeras) synthesis [1].		PROTACs
T17908	VHL Ligand-Linker Conjugates 15	E3 Ligase Ligand-Linker Conjugates 56	Others
	VHL Ligand-Linker Conjugates 15 is a chemical compound that combines a VHL ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. It is specifically designed for the creation of PROTACs[1].		Others
T17921	(S,R,S)-AHPC-PEG4-N3	VH032-PEG4-N3,VHL Ligand-Linker Conjugates 5,E3 ligase Ligand-Linker Conjugates 4	Others , PROTAC Linker
	(S,R,S)-AHPC-PEG4-N3 (VHL Ligand-Linker Conjugates 5) is a synthesized conjugate that functions as a ligand-linker in E3 ligase-based systems. It is composed of the (S,R,S)-AHPC VHL ligand and a 4-unit PEG linker, both c...		Others , PROTAC Linker
T17924	(S,R,S)-AHPC-PEG2-NH2 hydrochloride	VH032-PEG2-NH2 hydrochloride,VHL Ligand-Linker Conjugates 3 hydrochloride,E3 ligase Ligand-Linker Conjugates 6	Others , E3 Ligase Ligand-Linker Conjugate
	(S,R,S)-AHPC-PEG2-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 6) is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG2-NH2 hydrochloride incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit...		Others , E3 Ligase Ligand-Linker Conjugate
T79720	VHL-IN-1		HIF/HIF Prolyl-Hydroxylase
	VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α and enhances its transcriptional activity. It shows promise for appli...		HIF/HIF Prolyl-Hydroxylase
T17909	(S,R,S)-AHPC-PEG3-N3	VHL Ligand-Linker Conjugates 8,VH032-PEG3-N3,E3 ligase Ligand-Linker Conjugates 12	Others , E3 Ligase Ligand-Linker Conjugate , Ligand for E3 Ligase
	(S, R, S)-AHPC-PEG3-N3 (VHL Ligand-Linker Conjugates 8) is a synthesized E3 ligase ligand-linker conjugate. (S, R, S)-AHPC-PEG3-N3 incorporates the (S, R, S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC tec...
T18640	(S,R,S)-AHPC-C4-NH2 hydrochloride	VH032-C4-NH2 hydrochloride,E3 ligase Ligand-Linker Conjugates 28,VHL Ligand-Linker Conjugates 13	Others , Ligand for E3 Ligase
	(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and a linker.		Others , Ligand for E3 Ligase
T17920	(S,R,S)-AHPC-PEG1-N3	VHL Ligand-Linker Conjugates 9,VH032-PEG1-N3,E3 ligase Ligand-Linker Conjugates 3	Others , Ligand for E3 Ligase
	(S,R,S)-AHPC-PEG1-N3 (E3 ligase Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG1-N3 incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC tec...		Others , Ligand for E3 Ligase
T18600	VH032 thiol	VHL ligand 6	Others
	VH032 thiol (VHL ligand 6) is a VHL ligand that interacts with pan-BET inhibitor JQ1 through a linker to create a PROTAC[1] compound.		Others