vcp — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T40255	VCP/p97 inhibitor-1	VCP/p97 inhibitor-1
	VCP/p97 inhibitor-1, a highly effective compound, inhibits VCP/p97 (also known as Cdc48, CDC-48, or Ter94) with an IC 50 of 54.7 nM. This inhibitor induces a disruption in protein homeostasis and interferes with the degr...
T18871	VCP-Eribulin		Others
	VCP-Eribulin, an Eribulin-based drug for antibody conjugates[1], combines the VCP (ADCs linker) with Eribulin, a distinct microtubule inhibitor used in cancer treatments[2].		Others
T18279	Mal-PEG2-VCP-NB		Others
	Mal-PEG2-VCP-NB is a nonclaevable ADC linker containing a Maleimide group, 2-unit PEG and a VCP NB.		Others
T18278	Mal-PEG2-VCP-Eribulin		Others
	Mal-PEG2-VCP-Eribulin is a chemotherapeutic compound comprising an antibody-drug conjugate (ADC) linker (Mal-PEG2-VCP) and the microtubule inhibitor Eribulin[1]. This compound uniquely targets microtubules, offering a no...		Others
T9008	NPD8733		Others
	NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. It specifically binds to valosin-containing protein (VCP)/p97.		Others
T1853	NMS-873		p97
	NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.		p97
T3535	ML240		p97
	ML240 is a selective, ATP-competitive p97 inhibitor.		p97
T1969	DBEQ	JRF 12	Apoptosis , p97 , Autophagy
	DBEQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.		Apoptosis , p97 , Autophagy
T4684	ML241 hydrochloride		p97
	ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 may be a novel agent for the chemo...		p97
T6796	CB-5083	CB5083,CB 5083	p97
	CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).		p97
T29112	VPC171	VPC 171,VPC-171	Adenosine Receptor
	VPC171 is a novel adenosine A1 receptor positive allosteric modulator (PAM).		Adenosine Receptor
T70421	VCP746
	VCP-746 is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling. VCP746 reduces hypertrophy in a rat neonatal cardiac myocyte model. VCP746 is a hybrid molecule consisting of an adenosine moie...
T71930	APKC-I
	aPKC-I is an inhibitor of atypical protein kinase C (aPKC ) which inhibits both PKCζ and PKCι with high specificity and prevents VEGF-induced endothelial permeability in cell culture and in vivo, thereby blocking ischemi...
T33861	Paclitaxel-MVCP
	Paclitaxel-MVCP ( MC-val-cit-pab-paclitaxel )is a paclitaxel derivative with an MC-Val-Cit-PAB linker, which can be used for the preparation of Paclitaxel conjugates for drug delivery and nanomedicine research.
T31567	Doxorubicin-MVCP	MC-Val-Cit-PAB-Doxorubicin,MC-Val-Cit-PAB-Dox
	Doxorubicin-MVCP (MC-Val-Cit-PAB-Doxorubicin) is a Doxorubicin derivative with an MC-Val-Cit-PAB linker.
T12236	NMS-859	ZINC169324353	Others
	NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.		Others
T62148	NW 1028
	NW 1028 is a potent inhibitor of VCP/p97. NW 1028 selectively acts on the ND1L domain of p97 and inhibits the degradation of p97-dependent reporter genes. NW 1028 has a regulatory effect on the mitotic spindle.
T36570	KUS121
	KUS121 is a valosin-containing protein (VCP) modulator that inhibits VCP ATPase activity (IC50= 330 nM).1It inhibits cell death, ATP depletion, and upregulation of C/EBP-homologous protein (CHOP) induced by tunicamycin, ...