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Doxorubicin-MVCP

Catalog No. T31567 CAS T31567

Synonyms: MC-Val-Cit-PAB-Doxorubicin, MC-Val-Cit-PAB-Dox

Doxorubicin-MVCP (MC-Val-Cit-PAB-Doxorubicin) is a Doxorubicin derivative with an MC-Val-Cit-PAB linker.

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Doxorubicin-MVCP, CAS T31567

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Doxorubicin-MVCP (MC-Val-Cit-PAB-Doxorubicin) is a Doxorubicin derivative with an MC-Val-Cit-PAB linker.

Synonyms	MC-Val-Cit-PAB-Doxorubicin, MC-Val-Cit-PAB-Dox
Molecular Weight	1142.18
Formula	C56H67N7O19
CAS No.	T31567

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Chung SW, Lee BS, Choi Ju, Kim SW, Kim IS, Kim SY, Byun Y. Optimization of a Stable Linker Involved DEVD Peptide-Doxorubicin Conjugate That Is Activated upon Radiation-Induced Caspase-3-Mediated Apoptosis. J Med Chem. 2015 Aug 27;58(16):6435-47. doi: 10.1021/acs.jmedchem.5b00420. Epub 2015 Aug 18. PubMed PMID: 26263187. 2. Lin W, Xie X, Deng J, Liu H, Chen Y, Fu X, Liu H, Yang Y. Cell-penetrating peptide-doxorubicin conjugate loaded NGR-modified nanobubbles for ultrasound triggered drug delivery. J Drug Target. 2016 Feb;24(2):134-46. doi: 10.3109/1061186X.2015.1058802. Epub 2015 Jul 15. PubMed PMID: 26176270. 3. Yu Q, Wei Z, Shi J, Guan S, Du N, Shen T, Tang H, Jia B, Wang F, Gan Z. Polymer-Doxorubicin Conjugate Micelles Based on Poly(ethylene glycol) and Poly(N-(2-hydroxypropyl) methacrylamide): Effect of Negative Charge and Molecular Weight on Biodistribution and Blood Clearance. Biomacromolecules. 2015 Sep 14;16(9):2645-55. doi: 10.1021/acs.biomac.5b00460. Epub 2015 Aug 4. PubMed PMID: 26133354. 4. Mizusako H, Tagami T, Hattori K, Ozeki T. Active Drug Targeting of a Folate-Based Cyclodextrin-Doxorubicin Conjugate and the Cytotoxic Effect on Drug-Resistant Mammary Tumor Cells In Vitro. J Pharm Sci. 2015 Sep;104(9):2934-40. doi: 10.1002/jps.24428. Epub 2015 May 4. PubMed PMID: 25940848.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Doxorubicin-MVCP T31567 MC-Val-Cit-PAB-Doxorubicin MC-Val-Cit-PAB-Dox Doxorubicin MVCP DoxorubicinMVCP inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.