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Search Results for " vcp "

18

Compounds

9

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T40255 VCP/p97 inhibitor-1 VCP/p97 inhibitor-1
VCP/p97 inhibitor-1, a highly effective compound, inhibits VCP/p97 (also known as Cdc48, CDC-48, or Ter94) with an IC 50 of 54.7 nM. This inhibitor induces a disruption in protein homeostasis and interferes with the degr...
T18871 VCP-Eribulin Others
VCP-Eribulin, an Eribulin-based drug for antibody conjugates[1], combines the VCP (ADCs linker) with Eribulin, a distinct microtubule inhibitor used in cancer treatments[2].
T18278 Mal-PEG2-VCP-Eribulin Others
Mal-PEG2-VCP-Eribulin is a chemotherapeutic compound comprising an antibody-drug conjugate (ADC) linker (Mal-PEG2-VCP) and the microtubule inhibitor Eribulin[1]. This compound uniquely targets microtubules, offering a no...
T18279 Mal-PEG2-VCP-NB Others
Mal-PEG2-VCP-NB is a nonclaevable ADC linker containing a Maleimide group, 2-unit PEG and a VCP NB.
T9008 NPD8733 Others
NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. It specifically binds to valosin-containing protein (VCP)/p97.
T1853 NMS-873 p97
NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.
T3535 ML240 p97
ML240 is a selective, ATP-competitive p97 inhibitor.
T1969 DBEQ JRF 12 Apoptosis , p97 , Autophagy
DBEQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.
T4684 ML241 hydrochloride p97
ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 may be a novel agent for the chemo...
T29112 VPC171 VPC 171,VPC-171 Adenosine Receptor
VPC171 is a novel adenosine A1 receptor positive allosteric modulator (PAM).
T6796 CB-5083 CB5083,CB 5083 p97
CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).
T70421 VCP746
VCP-746 is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling. VCP746 reduces hypertrophy in a rat neonatal cardiac myocyte model. VCP746 is a hybrid molecule consisting of an adenosine moie...
T71930 APKC-I
aPKC-I is an inhibitor of atypical protein kinase C (aPKC ) which inhibits both PKCζ and PKCι with high specificity and prevents VEGF-induced endothelial permeability in cell culture and in vivo, thereby blocking ischemi...
T33861 Paclitaxel-MVCP
Paclitaxel-MVCP ( MC-val-cit-pab-paclitaxel )is a paclitaxel derivative with an MC-Val-Cit-PAB linker, which can be used for the preparation of Paclitaxel conjugates for drug delivery and nanomedicine research.
T31567 Doxorubicin-MVCP MC-Val-Cit-PAB-Doxorubicin,MC-Val-Cit-PAB-Dox
Doxorubicin-MVCP (MC-Val-Cit-PAB-Doxorubicin) is a Doxorubicin derivative with an MC-Val-Cit-PAB linker.
T12236 NMS-859 ZINC169324353 Others
NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
T62148 NW 1028
NW 1028 is a potent inhibitor of VCP/p97. NW 1028 selectively acts on the ND1L domain of p97 and inhibits the degradation of p97-dependent reporter genes. NW 1028 has a regulatory effect on the mitotic spindle.
T36570 KUS121
KUS121 is a valosin-containing protein (VCP) modulator that inhibits VCP ATPase activity (IC50= 330 nM).1It inhibits cell death, ATP depletion, and upregulation of C/EBP-homologous protein (CHOP) induced by tunicamycin, ...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-01013 VCP Protein, Human, Recombinant (His) Human E. coli
Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxi...
TMPH-01909 CPVL Protein, Human, Recombinant (His & SUMO) Human E. coli
May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation. CPVL Protein, Human, Recombinant (His & SU...
TMPH-03665 Vaccinia virus (strain Copenhagen) OPG185 Protein (His) VACV E. coli
Prevents cell to cell fusion by interacting with and directing the viral K2 protein on the host plasma membrane. The A56-K2 complex associates with components of the entry fusion complex (EFC) presumably to avoid superin...
TMPH-01260 AMFR Protein, Human, Recombinant (hFc) Human HEK293 Cells
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPH-01259 AMFR Protein, Human, Recombinant (His) Human E. coli
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPH-01270 TRAIP Protein, Human, Recombinant (His) Human E. coli
E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethe...
TMPH-02282 Ubiquilin-1 Protein, Human, Recombinant (His & Myc) Human E. coli
Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pa...
TMPH-02632 TRIM21 Protein, Mouse, Recombinant (E. coli, His) Mouse E. coli
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of...
TMPH-02633 TRIM21 Protein, Mouse, Recombinant (His) Mouse Baculovirus Insect Cells
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of...
TargetMol