trastuzumab — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9912	Trastuzumab		EGFR
	Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2. Trastuzumab has been clinically used to treat HER2 Positive Metastatic Breast Cancer and HER2 Positive Gastr...		EGFR
T36646	Trastuzumab deruxtecan	DS-8201a,VRN-101099,DS 8201,T-DXd	Others
	Trastuzumab deruxtecan (T-DXd) is an antibody-activated molecule coupling (ADC) with anticancer and antitumour activity.Trastuzumab deruxtecan has been shown to have an ameliorative effect in HER2-positive breast and gas...		Others
T80955	Trastuzumab duocarmazine	(vic)-Trastuzumab duocarmazine
	Trastuzumab duocarmazine ((vic)-Trastuzumab duocarmazine) is an ADC targeting HER2 that undergoes cleavage by histone B within tumor cells, thereby achieving selective targeting of these cells. It exhibits antitumor acti...
T36647	Trastuzumab emtansine		Others
	Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that combines the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of DM1, a microtubule-inhibitory deriv...		Others
T76971	Trastuzumab beta
	Trastuzumab beta (ABP 980), a biosimilar to Trastuzumab, is a monoclonal antibody (McAb) that targets the human epidermal growth factor receptor 2 (HER2). It is utilized in the research of HER2-positive metastatic breast...
T9996	NCT-58	NCT58	HSP
	NCT-58 is a potent C-terminal HSP90 inhibitor. NCT-58 does not induce the heat shock response (HSR). NCT-58 elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of ...		HSP
T38889	Thailanstatin A
	Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 =650 nM). Thailanstatin A inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the s...
T81288	Rezetecán
	Rezetecán serves as a precursor for synthesizing Trastuzumab rezetecan, an antineoplastic agent [1].
T36669	IYPTNGYTR acetate
	IYPTNGYTR acetate, a deamidation-sensitive peptide derived from Trastuzumab, is a suitable tool for monitoring the metabolism of Trastuzumab in vivo [1].
T81084	STING agonist-18
	STING Agonist-18 (Compound 1a) is a precursor for the synthesis of antibody-drug conjugates (ADCs), including Trastuzumab conjugates [1].
T11936	Macropa-NCS		Others
	Macropa-NCS is conjugated to trastuzumab as well as to the prostate-specific membrane antigen-targeting compound RPS-070.		Others
T38023	FTISADTSK acetate
	FTISADTSK acetate is a stable endogenous signature peptide sourced from Trastuzumab, which can be monitored using selected reaction monitoring (SRM)[1].
T38906	IYPTNGYTR
	IYPTNGYTR, a deamidation-sensitive peptide, is a deamidation derivative of Trastuzumab. This compound, IYPTNGYTR, can be utilized for monitoring Trastuzumab metabolism in vivo.
T74940	Anticancer agent 81		Apoptosis
	Anticancer agent 81 (Compound 37b3) induces tumor cell cycle arrest and apoptosis and serves as a payload for conjugation with Trastuzumab, resulting in the antibody-agent conjugate (ADC) T-PBA. T-PBA retains the targeti...		Apoptosis
T38907	FTISADTSK
	FTISADTSK is an endogenous stable signature peptide derived from Trastuzumab, which can be accurately assessed using selected reaction monitoring (SRM).
T15872	M-PEG4-Br		Others
	m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab. m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrop...		Others
T77885	(Aminooxy)acetamide-Val-Cit-PAB-MMAE
	(Aminooxy)acetamide-Val-Cit-PAB-MMAE (MMAE 5) serves as an intermediate for synthesizing drug-linker conjugates in antibody-drug conjugates (ADCs). This compound is first conjugated to a polyamide through oxime bond form...
T16008	Maleimido-tri(ethylene glycol)-propionic acid	Mal-PEG3-acid	Others
	Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin...		Others
T36648	Tucatinib hemiethanolate
	Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM. Tucatinib hemiethanolate has nanomolar activity against purified HER2 enzyme and is approximately 500-f...