tlr — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13932	TLR1		Others , MyD88
	TLR1 is a cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic and inhibits IL-1 receptor-mediated responses.		Others , MyD88
T8503	TLR4-IN-C34		TLR
	TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis		TLR
T13167	TLR7/8 agonist 3		TLR
	TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.		TLR
T2S0265	Robinin	NSC 9222	TLR
	Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LR...		TLR
T4258	TLR7 agonist 2	TLR7-agonist-1,TLR7-IN-1	TLR
	TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).		TLR
T39669	TLR7/8/9-IN-1	TLR7/8/9-IN-1	TLR
	TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.		TLR
T7317	CU-CPT-9a		TLR
	CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-		TLR
T22698	TLR3-IN-1	CU CPT 4a	TLR
	TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cell...		TLR
T15020	CU-CPT22		TLR
	CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 binds at the interface of TLR1 and TLR2 (IC50 = 0.58 μM). It competes with the synthetic triacylated lipoprotein (Pam3CSK4) ...		TLR
TN2008	Okanin		NF-κB , TLR
	Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.		NF-κB , TLR
T10899	CU-CPT17e		TLR
	CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).		TLR
T11598	IAXO-102		TLR
	IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdomin...		TLR
T9570	Enpatoran		TLR
	Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo.		TLR
T7672	MD2-TLR4-IN-1		TLR
	MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.		TLR
T5561	TLR7/8 agonist 1 dihydrochloride	TLR7/8 agonist-5d	TLR
	TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) is a TLR7/8 agonist which shows prominent immunostimulatory activities.		TLR
T4231	MD2-IN-1		TLR
	MD2-IN-1 is a Myeloid differentiation protein 2 (MD2) inhibitor with a KD of 189 μM for the recombinant human MD2 (rhMD2).		TLR
T15777	Loxoribine	RWJ 21757,7-Allyl-8-oxoguanosine	Influenza Virus , TLR
	Loxoribine (RWJ 21757) is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant ...		Influenza Virus , TLR
T38078	TLR7/8-IN-1	TLR7/8-IN-1	TLR
	TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor, is a valuable compound for autoimmune disease research[1].		TLR
T39654	Afimetoran	BMS-986256	TLR
	Afimetoran (BMS-986256) is a toll-like receptor antagonist. Afimetoran can be used in the research of inflammatory and autoimmune diseases.		TLR
T16506	PF-4878691	3M-852A	TLR
	PF-4878691 (3M-852A) is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.		TLR