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TLR3-IN-1

Catalog No. T22698 CAS 1279713-77-7

Synonyms: CU CPT 4a

TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cells.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

TLR3-IN-1, CAS 1279713-77-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
2 mg	In stock	$ 68.00
5 mg	In stock	$ 116.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 418.00
50 mg	In stock	$ 625.00
100 mg	In stock	$ 889.00
500 mg	In stock	$ 1,790.00
1 mL * 10 mM (in DMSO)	In stock	$ 128.00

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Purity: 97.77%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cells.
Targets&IC50	TLR3:3.44 μM (in RAW 264.7 cells)

Synonyms	CU CPT 4a
Molecular Weight	377.82
Formula	C18H13ClFNO3S
CAS No.	1279713-77-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (132.34 mM)

References and Literature

1. Cheng K , Wang X , Yin H . Small-Molecule Inhibitors of the TLR3/dsRNA Complex[J]. Journal of the American Chemical Society, 2011, 133(11):p.3764-3767.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library NO PAINS Compound Library Bioactive Compound Library Pyroptosis Compound Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library Immuno-Oncology Compound Library

Related Products

Related compounds with same targets

PF-4878691 Capillarisin TLR7 agonist 1 Chloroquine phosphate Schaftoside TH1020 Loxoribine CU-T12-9

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TLR3-IN-1 1279713-77-7 Immunology/Inflammation TLR TLR3/dsRNA complex inhibit CU-CPT 4a TNF-α protein-RNA interaction CU CPT 4a IL-1β TLR-3-IN-1 Inhibitor TLR3 IN 1 TLR3IN1 Toll-like Receptor (TLR) inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.