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Search Results for " tgr5 "

20

Compounds

Cat No. Product Name Synonyms Targets
T1824 TGR5 Receptor Agonist GPCR19
TGR5 is a potent TGR5(GPCR19) agonist.
T40302 FXR/TGR5 agonist 1
FXR/TGR5 agonist 1 acts as an agonist on both FXR and TGR5 receptors and is utilized for treating fatty liver disease.
T74825 TGR5 agonist 2
TGR5 agonist 2 (compound 19) serves as a highly potent agonist of TGR5, demonstrating an EC50 value of 0.27 µM [1].
T79425 TGR5 agonist 4
TGR5 agonist 4 (compound 19), a derivative of cholic acid, selectively activates the TGR5 receptor with an effective concentration (EC50) of 4 μM [1].
T74824 TGR5 agonist 1
Compound 18 (TGR5 agonist 1) is a potent agonist of TGR5, exhibiting an EC50 value of 0.31 µM [1].
T79424 TGR5 agonist 3
Compound 8, a cholic acid derivative, functions as a selective TGR5 agonist and exhibits an EC50 value of 5 μM [1].
T81000 TGR5 Receptor Agonist 4
TGR5 Receptor Agonist 4, a selective agonist for the Bile Acid Receptor (TGR5), exhibits potent activity with an EC50 of 2 nM for human TGR5 (hTGR5) and 3 nM for mouse TGR5 (mTGR5). It is notably involved in mediating hy...
T63554 TGR5 Receptor Agonist 3
TGR5 Receptor Agonist 3 is a G protein-coupled bile acid receptor 1 (GPBAR1, TGR5) agonist soft drug compound that decreases gallbladder filling, exhibits good gallbladder safety, and is able to act on hTGR5 (EC50: 16.4 ...
T7428 SBI-115 GPCR19
SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5
T4083 BAR501 BAR 501 GPCR19
BAR501 is an effective and specific GPBAR1 agonist (EC50: 1 μM).
TQ0252 BAR502 FXR , GPCR19 , Autophagy
BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).
T4352 SB756050 SB-756050,SB 756050 GPCR19
SB756050 is a specific TGR5 agonist.
T0700 Ursodeoxycholic acid UDCA,Ursodiol Potassium Channel , Endogenous Metabolite
Ursodeoxycholic acid (UDCA) can be used to dissolve gallstones and reduce cholesterol absorption.
T5077 Deoxycholic acid sodium salt Sodium deoxycholate,Sodium Desoxycholate Endogenous Metabolite , GPCR19
Deoxycholic acid sodium salt (Sodium deoxycholate) can activate the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.
T2968 Hyodeoxycholic acid NSC 60672,α-Hyodeoxycholic Acid,HDCA FXR , Endogenous Metabolite , GPCR19
Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.
T2965 Deoxycholic acid Cholorebic,Deoxycholate,Desoxycholic acid,Cholanoic Acid,Cholerebic Endogenous Metabolite , GPCR19
Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorptio...
T8818 TC-G 1005 GPCR19
TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.
T29078 Ursodeoxycholic acid sodium UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium FXR , Endogenous Metabolite , GPCR19
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeoxycholic acid sodium acts as signaling molecule, exerting it...
T11662L INT-777 S-EMCA GPCR19
INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats...
T11662 INT-777 R-enantiomer S-EMCA R enantiomer Others
INT-777 is the R-enantiomer of INT-777, less potent than INT-777,EC50 of 4.79 μM for TGR5.
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