tafi — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9339	Stafia-1		STAT
	Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.		STAT
T27122	Dasantafil	SCH446132,SCH-446132,SCH 446132	PDE
	Dasantafil (SCH446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to treat genitourinary disorders and study erectile dysfunction.		PDE
T16724	Razuprotafib	AKB-9778	Phosphatase , Others
	Razuprotafib (AKB-9778) is a protein tyrosine phosphatase ß (HPTPß) inhibitor (IC50: 50 nM). Razuprotafib is effective for the activation of Tie-2 and is protective against acute kidney injury.		Phosphatase , Others
T61699	Osunprotafib	AC 484,Osunprotafib,AC484,ABBV-CLS-484	Phosphatase
	ABBV-CLS-484 (Osunprotafib) is a potent PTPN2 inhibitor with subnanomolar activity and antitumor activity that enhances T-cell anti-tumor immunity.ABBV-CLS-484 can be used for the treatment of neoplasms, esophageal cance...		Phosphatase
T9646	Stafib-2		STAT
	Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM, respectively.Stafib-2 has poor cell permeability.		STAT
T70150	Capstafin
	Capstafin is a highly potent and selective inhibitor of STAT5b.
T70149	PomCapstafin
	PomCapstafin is a prodrug of Capstafin, acting as a potent, selective STAT5b inhibitor.
T73739	Pomstafib-2
	Pomstafib-2, a potent and selective inhibitor of STAT5b, reduces pSTAT5b expression and effectively induces apoptosis [1] [2].
T24838	Stafib-1	Stafib 1,Stafib1	STAT
	Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.		STAT
T15243	Ertiprotafib	PTP 112	Phosphatase , PPAR
	Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ).		Phosphatase , PPAR
T79049	Tegeprotafib	PTPN2/1-IN-1	Phosphatase
	Tegeprotafib (PTPN2/1-IN-1) (Compound 124) is an orally active inhibitor targeting both PTPN2 and PTPN1B, displaying potent IC50 values at 4.4 nM for PTPN2 and 1-10 nM for PTPN1B, respectively [1].		Phosphatase
T35917	Stafia-1-dipivaloyloxymethyl ester
	Stafia-1-dipivaloyloxymethyl ester (compound 27) demonstrated a dose-dependent reduction in pSTAT5a expression (0-200 μM) while showing no discernible effect on pSTAT5b[1].
T11668	IQB-782		Others
	IQB-782 is a mucolytic agent with mucolytic expectorant activity.IQB-782 inhibits thrombin-activating fibrinolytic inhibitor (TAFI), protects rats from tobacco smoke-induced respiratory obstruction, reduces the viscosity...		Others
T82286	Glycylglycylcysteine
	Glycylglycylcysteine is an inhibitor of Thrombin Activatable Fibrinolysis Inhibitor (TAFI), exhibiting a K_i value of 0.99 µM and an IC_50 of 9.4 µM in TAFI substrate assays. TAFI, a basic carboxypeptidase, hinders fibri...
T69294	UK‑396082
	UK-396082 is a potent inhibitor of thrombin-activated fibrinolytic inhibitor (TAFI), enhancing plasmin activity while concurrently reducing levels of the extracellular matrix (ECM). This compound is valuable for research...

Compounds

Stafia-1

T9339

Synonym: SCH446132,SCH-446132,SCH 446132

Target: Phosphatase, Others

Osunprotafib

T61699

Synonym: AC 484,Osunprotafib,AC484,ABBV-CLS-484

Synonym: Stafib 1,Stafib1

Target: Phosphatase, PPAR

Tegeprotafib

T79049

Synonym: PTPN2/1-IN-1

Target: Phosphatase

Stafia-1-dipivaloyloxymethyl ester

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01631	Carboxypeptidase B2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Carboxypeptidase B2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47.4 kDa and the accession number is Q96IY4-1.
TMPY-02505	Carboxypeptidase B2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Carboxypeptidase B2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48 kDa and the accession number is Q9JHH6.
TMPJ-00649	CPB2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Carboxypeptidase B2 (CPB2) is a secreted enzyme that belongs to the peptidase M14 family. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen by the liver and circulates in the pl...
TMPJ-00857	Thrombomodulin Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Thrombomodulin is also known as CD141 antigen and blood dendritic cell antigen 3 (BDCA3), which is encoded by the THBD gene. The deduced amino acid sequence of mouse THBD predicts a signal peptide (aa 1 to 16) and a matu...