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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4253 | Skp2 Inhibitor C1 | SKPin C1 | Others , E1/E2/E3 Enzyme |
Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation. | |||
T78194 | Skp2 inhibitor 2 | E1/E2/E3 Enzyme | |
Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1. This compound targets Skp2, a component of cullin-RING ligases that recruit... | |||
T13244 | Ubiquitination-IN-1 | Others | |
Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM). | |||
T72043 | SCFSkp2-IN-2 | Apoptosis , E1/E2/E3 Enzyme | |
SCFSkp2-IN-2, a Skp2 inhibitor, exhibits a dissociation constant (K_D) of 28.77 μM. It demonstrates antitumor activities by inducing apoptosis in non-small cell lung cancer (NSCLC) cells. | |||
T3317 | SZL P1-41 | Apoptosis , Others , E1/E2/E3 Enzyme | |
SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediate... | |||
T16901 | SMIP004 | Apoptosis , Others , E1/E2/E3 Enzyme | |
SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells. | |||
T77516 | SARS-CoV-2-IN-39 | Antiviral , SARS-CoV | |
SARS-CoV-2-IN-39 is a SARS-CoV-2 inhibitor with an EC50 of 1 μM. SARS-CoV-2-IN-39 has antiviral activity and inhibits SARS-CoV-2 by inhibiting SKP2 protein and stabilizing BECN1. | |||
T25889 | NSC-689857 | NSC 689857,NSC689857 | |
NSC-689857 is an inhibitor that acts in the Skp2-Cks1 protein-protein interaction and p27Kip1 ubiquitination in vitro. | |||
T71830 | DT204 | ||
DT204 is a SCFSkp2 inhibitor which blocks Skp2 binding to Cullin-1 and Commd1, thereby synergistically enhancing BTZ-induced apoptosis and stabilization. DT204 also increases p27 levels. | |||
T68845 | Americanin A | ||
Americanin A natural thrombin inhibitor, suppressing melanin synthesis, regulating the ATM/ATR signaling pathway and the Skp2-p27 axis in human colon cancer cells. |