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Skp2 Inhibitor C1

Catalog No. T4253   CAS 432001-69-9
Synonyms: SKPin C1

Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.

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Skp2 Inhibitor C1 Chemical Structure
Skp2 Inhibitor C1, CAS 432001-69-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 36.00
5 mg In stock $ 84.00
10 mg In stock $ 137.00
25 mg In stock $ 293.00
50 mg In stock $ 490.00
100 mg In stock $ 715.00
1 mL * 10 mM (in DMSO) In stock $ 86.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.
In vitro in vitro: T47D cells treated with C1 (5 μM for 16 hours) displayed an increase in G1 phase (p < 0.0001) and a decrease in S phase (p < 0.0001), correlating with p27 protein induction. In contrast, MCF-7 cells responded to C1 with a significant reduction in G1 phase (35%, p < 0.0001) and an increase in G2-M phase (43%, p < 0.0001). This G1 reduction and G2/M arrest is dose dependent on C1 and correlates with increased p27 protein levels.
Kinase Assay To test enzyme activity of NOS, the lysate from RAW264.7 cells (a protein concentration of 37.5 μg/200 μL) is incubated for 3 h at 37°C with 100 mM of L-arginine in the presence of Esonarimod (KE-298) and the conversion of L-arginine to nitrite is monitored.
Synonyms SKPin C1
Molecular Weight 465.34
Formula C18H13BrN2O4S2
CAS No. 432001-69-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6.4 mg/mL, sonification is recommended.

TargetMolReferences and Literature

1. Wu L, et al. Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem Biol. 2012 Dec 21;19(12):1515-24. 2. Pavlides SC, et al. Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: therapeutic potential for endometrial cancer. Endocrinology. 2013 Nov;154(11):4030-45.

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Bioactive Compounds Library Max Inhibitor Library HIF-1 Signaling Pathway Compound Library Target-Focused Phenotypic Screening Library Ubiquitination Compound Library Bioactive Compound Library Covalent Inhibitor Library

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Keywords

Skp2 Inhibitor C1 432001-69-9 Others Ubiquitination E1/E2/E3 Enzyme Ubiquitin conjugating enzyme E1 activating enzyme Skp-2 Inhibitor C1 E3 ligating enzyme Ubiquitin activating enzyme SKPin C 1 E2 conjugating enzyme Ubiquitin ligase SKPin C-1 Inhibitor SKPin C1 inhibit inhibitor

 

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