Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 36.00 | |
5 mg | In stock | $ 84.00 | |
10 mg | In stock | $ 137.00 | |
25 mg | In stock | $ 293.00 | |
50 mg | In stock | $ 490.00 | |
100 mg | In stock | $ 715.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 86.00 |
Description | Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation. |
In vitro | in vitro: T47D cells treated with C1 (5 μM for 16 hours) displayed an increase in G1 phase (p < 0.0001) and a decrease in S phase (p < 0.0001), correlating with p27 protein induction. In contrast, MCF-7 cells responded to C1 with a significant reduction in G1 phase (35%, p < 0.0001) and an increase in G2-M phase (43%, p < 0.0001). This G1 reduction and G2/M arrest is dose dependent on C1 and correlates with increased p27 protein levels. |
Kinase Assay | To test enzyme activity of NOS, the lysate from RAW264.7 cells (a protein concentration of 37.5 μg/200 μL) is incubated for 3 h at 37°C with 100 mM of L-arginine in the presence of Esonarimod (KE-298) and the conversion of L-arginine to nitrite is monitored. |
Synonyms | SKPin C1 |
Molecular Weight | 465.34 |
Formula | C18H13BrN2O4S2 |
CAS No. | 432001-69-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6.4 mg/mL, sonification is recommended.
You can also refer to dose conversion for different animals. More
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Skp2 Inhibitor C1 432001-69-9 Others Ubiquitination E1/E2/E3 Enzyme Ubiquitin conjugating enzyme E1 activating enzyme Skp-2 Inhibitor C1 E3 ligating enzyme Ubiquitin activating enzyme SKPin C 1 E2 conjugating enzyme Ubiquitin ligase SKPin C-1 Inhibitor SKPin C1 inhibit inhibitor